PTK6

PTK6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RJA, 2KGT
Dynodwyr
Cyfenwau	PTK6, BRK, protein tyrosine kinase 6
Dynodwyr allanol	OMIM: 602004 HomoloGene: 68494 GeneCards: PTK6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • signaling receptor binding • ATP binding • protein tyrosine kinase activity Cydrannau o'r gell • cytoplasm • cell projection • bilen • ruffle • extrinsic component of cytoplasmic side of plasma membrane • cnewyllyn cell • nucleoplasm • cytosol • Cellbilen • nuclear body Prosesau biolegol • cellular response to retinoic acid • negative regulation of growth • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • protein phosphorylation • negative regulation of protein tyrosine kinase activity • regulation of cell population proliferation • intestinal epithelial cell differentiation • positive regulation of neuron projection development • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • innate immune response • cell migration • positive regulation of cell cycle • ERBB2 signaling pathway • negative regulation of signal transduction • positive regulation of epidermal growth factor receptor signaling pathway • tyrosine phosphorylation of STAT protein • positive regulation of tyrosine phosphorylation of STAT protein • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5753	n/a
Ensembl	ENSG00000101213	n/a
UniProt	Q13882	n/a
RefSeq (mRNA)	NM_001256358 NM_005975	n/a
RefSeq (protein)	NP_001243287 NP_005966	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTK6 yw PTK6 a elwir hefyd yn Protein tyrosine kinase 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTK6.

• BRK

Llyfryddiaeth

• "Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. ". Mol Cancer Res. 2016. PMID 26983689.
• "Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition. ". Biochemistry. 2015. PMID 25940761.
• "Co-crystal structures of PTK6: With Dasatinib at 2.24 Ã…, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Ã… resolution. ". Biochem Biophys Res Commun. 2017. PMID 27993680.
• "Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Ã… resolution. ". Biochem Biophys Res Commun. 2016. PMID 27480927.
• "The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer.". Chin J Cancer. 2016. PMID 27311570.