PTGS2

PTGS2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
Dynodwyr
Cyfenwau	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2
Dynodwyr allanol	OMIM: 600262 HomoloGene: 31000 GeneCards: PTGS2
EC number	1.14.99.1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• arachidonate 15-lipoxygenase activity; • metal ion binding; • heme binding; • enzyme binding; • oxidoreductase activity; • protein homodimerization activity; • dioxygenase activity; • GO:0001948, GO:0016582 protein binding; • peroxidase activity; • prostaglandin-endoperoxide synthase activity; • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; • transferase activity;
Cydrannau o'r gell	• cytoplasm; • endoplasmic reticulum lumen; • bilen; • caveola; • neuron projection; • organelle membrane; • Reticwlwm endoplasmig; • intracellular membrane-bounded organelle; • endoplasmic reticulum membrane; • GO:0009327 protein-containing complex;
Prosesau biolegol	• response to fructose; • learning; • response to organic substance; • lipoxygenase pathway; • cellular response to mechanical stimulus; • response to manganese ion; • angiogenesis; • cellular response to hypoxia; • embryo implantation; • negative regulation of cell population proliferation; • response to cytokine; • negative regulation of smooth muscle contraction; • Cof; • GO:0001306 response to oxidative stress; • maintenance of blood-brain barrier; • response to lithium ion; • response to tumor necrosis factor; • fatty acid biosynthetic process; • positive regulation of synaptic transmission, glutamatergic; • positive regulation of vasoconstriction; • response to organonitrogen compound; • inflammatory response; • positive regulation of smooth muscle contraction; • bone mineralization; • response to fatty acid; • response to vitamin D; • cellular response to UV; • positive regulation of fever generation; • cellular response to fluid shear stress; • positive regulation of synaptic plasticity; • regulation of blood pressure; • response to lipopolysaccharide; • positive regulation of platelet-derived growth factor production; • regulation of inflammatory response; • brown fat cell differentiation; • sensory perception of pain; • response to radiation; • prostaglandin biosynthetic process; • cellular response to ATP; • ovulation; • positive regulation of smooth muscle cell proliferation; • hair cycle; • response to estradiol; • positive regulation of cell death; • positive regulation of cell migration involved in sprouting angiogenesis; • GO:1904578 response to organic cyclic compound; • lipid metabolism; • positive regulation of nitric oxide biosynthetic process; • response to glucocorticoid; • cyclooxygenase pathway; • fatty acid metabolic process; • positive regulation of fibroblast growth factor production; • decidualization; • regulation of cell population proliferation; • positive regulation of cell population proliferation; • negative regulation of calcium ion transport; • positive regulation of apoptotic process; • positive regulation of transforming growth factor beta production; • positive regulation of vascular endothelial growth factor production; • positive regulation of brown fat cell differentiation; • negative regulation of synaptic transmission, dopaminergic; • cellular oxidant detoxification; • GO:0010260 heneiddio; • NAD biosynthesis via nicotinamide riboside salvage pathway; • cellular response to heat; • positive regulation of prostaglandin biosynthetic process; • positive regulation of peptidyl-serine phosphorylation; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to non-ionic osmotic stress; • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; • cellular response to lead ion; • response to angiotensin; • prostaglandin metabolic process; • positive regulation of protein import into nucleus; • cytokine-mediated signaling pathway; • long-chain fatty acid biosynthetic process; • negative regulation of cell cycle; • regulation of neuroinflammatory response;
	Sources:Amigo / QuickGO
Orthologau
	5743
	n/a
	ENSG00000073756
	n/a
	P35354
	n/a
	NM_000963
	n/a
	NP_000954
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTGS2 yw PTGS2 a elwir hefyd yn Prostaglandin-endoperoxide synthase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q31.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTGS2.

COX2
COX-2
PHS-2
PGG/HS
PGHS-2
hCox-2
GRIPGHS

Llyfryddiaeth[golygu | golygu cod]

"Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis. ". World J Gastroenterol. 2017. PMID 28405152.
"Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients. ". J Cancer Res Ther. 2016. PMID 28230039.
"Cyclooxygenase 2 contributes to bradykinin-induced microvascular responses in peripheral arterioles after cardiopulmonary bypass. ". J Surg Res. 2017. PMID 28985857.
"Cyclooxygenase-2 Inhibition Enhances Proliferation of NKT Cells Derived from Patients with Laryngeal Cancer. ". Anticancer Res. 2017. PMID 28739688.
"Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations.". Environ Res. 2017. PMID 28709031.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] PTGS2 - Cronfa NCBI

[1]

[2]