PTBP1

PTBP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QM9, 1SJQ, 1SJR, 2AD9, 2ADB, 2ADC, 2EVZ, 3ZZY, 3ZZZ
Dynodwyr
Cyfenwau	PTBP1, HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB, polypyrimidine tract binding protein 1
Dynodwyr allanol	OMIM: 600693 HomoloGene: 49188 GeneCards: PTBP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • pre-mRNA binding • GO:0001948, GO:0016582 protein binding • poly-pyrimidine tract binding • nucleic acid binding • RNA binding Cydrannau o'r gell • nucleolus • extracellular exosome • bilen • cnewyllyn cell • nucleoplasm Prosesau biolegol • mRNA splicing, via spliceosome • mRNA processing • negative regulation of mRNA splicing, via spliceosome • regulation of alternative mRNA splicing, via spliceosome • negative regulation of RNA splicing • RNA splicing • negative regulation of muscle cell differentiation • fibroblast growth factor receptor signaling pathway • IRES-dependent viral translational initiation • RNA metabolic process • positive regulation of protein dephosphorylation • positive regulation of calcineurin-NFAT signaling cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5725	n/a
Ensembl	ENSG00000011304	n/a
UniProt	P26599	n/a
RefSeq (mRNA)	NM_002819 NM_031990 NM_031991 NM_175847	n/a
RefSeq (protein)	NP_002810 NP_114367 NP_114368	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTBP1 yw PTBP1 a elwir hefyd yn Polypyrimidine tract-binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTBP1.

• PTB
• PTB2
• PTB3
• PTB4
• pPTB
• HNRPI
• PTB-1
• PTB-T
• HNRNPI
• HNRNP-I

Llyfryddiaeth

• "Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. ". Elife. 2016. PMID 26744779.
• "Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes. ". BMC Med Genet. 2015. PMID 25927630.
• "Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. ". Elife. 2016. PMID 27882870.
• "Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. ". Biochem Soc Trans. 2016. PMID 27528752.
• "Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.". Hum Mol Genet. 2016. PMID 27378699.