PSMD4

PSMD4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF
Dynodwyr
Cyfenwau	PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Dynodwyr allanol	OMIM: 601648 HomoloGene: 55691 GeneCards: PSMD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • polyubiquitin modification-dependent protein binding • GO:0001948, GO:0016582 protein binding • identical protein binding • RNA binding Cydrannau o'r gell • nucleoplasm • proteasome complex • cnewyllyn cell • cytosol • proteasome accessory complex • proteasome regulatory particle, base subcomplex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • ubiquitin-dependent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5710	n/a
Ensembl	ENSG00000159352	n/a
UniProt	P55036	n/a
RefSeq (mRNA)	NM_002810 NM_153822 NM_001330692	n/a
RefSeq (protein)	NP_001317621 NP_002801	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMD4 yw PSMD4 a elwir hefyd yn Proteasome 26S subunit, non-ATPase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMD4.

• AF
• ASF
• S5A
• AF-1
• MCB1
• Rpn10
• pUB-R5

Llyfryddiaeth

• "Impaired assembly and post-translational regulation of 26S proteasome in human end-stage heart failure. ". Circ Heart Fail. 2013. PMID 23515276.
• "Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3. ". Blood. 2011. PMID 21628408.
• "Quantitative Affinity Interaction of Ubiquitinated and Non-ubiquitinated Proteins with Proteasome Subunit Rpn10. ". Biochemistry (Mosc). 2017. PMID 28988533.
• "VWA domain of S5a restricts the ability to bind ubiquitin and Ubl to the 26S proteasome. ". Mol Biol Cell. 2014. PMID 25318673.
• "Reduction of angiocidin contributes to decreased HepG2 cell proliferation.". Afr Health Sci. 2013. PMID 24250289.