PSMD10

PSMD10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QYM, 1TR4, 1UOH, 4NIK
Dynodwyr
Cyfenwau	PSMD10, dJ889N15.2, p28, p28(GANK), proteasome 26S subunit, non-ATPase 10
Dynodwyr allanol	OMIM: 300880 HomoloGene: 94517 GeneCards: PSMD10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transcription factor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • intermediate filament cytoskeleton • cytoplasm • nucleoplasm • proteasome regulatory particle, base subcomplex • cnewyllyn cell • proteasome regulatory particle • proteasome complex • cytosol Prosesau biolegol • negative regulation of release of cytochrome c from mitochondria • cytoplasmic sequestering of NF-kappaB • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of cell growth • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of MAPK cascade • negative regulation of DNA damage response, signal transduction by p53 class mediator • proteasome regulatory particle assembly • positive regulation of protein ubiquitination • negative regulation of NF-kappaB transcription factor activity • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of apoptotic process • GO:0097285 apoptotic process • protein deubiquitination • post-translational protein modification • MAPK cascade • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of cellular amino acid metabolic process • negative regulation of G2/M transition of mitotic cell cycle • anaphase-promoting complex-dependent catabolic process • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • tumor necrosis factor-mediated signaling pathway • NIK/NF-kappaB signaling • Fc-epsilon receptor signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of mRNA stability • T cell receptor signaling pathway • transmembrane transport • Wnt signaling pathway, planar cell polarity pathway • regulation of transcription from RNA polymerase II promoter in response to hypoxia • interleukin-1-mediated signaling pathway • negative regulation of canonical Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway • regulation of mitotic cell cycle phase transition • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5716	n/a
Ensembl	ENSG00000101843	n/a
UniProt	O75832	n/a
RefSeq (mRNA)	NM_170750 NM_002814	n/a
RefSeq (protein)	NP_002805 NP_736606	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMD10 yw PSMD10 a elwir hefyd yn Proteasome 26S subunit, non-ATPase 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMD10.

• p28
• p28(GANK)
• dJ889N15.2

Llyfryddiaeth

• "Gankyrin regulates cell signaling network. ". Tumour Biol. 2016. PMID 26819208.
• "Clinicopathologic features and prognostic implications of Gankyrin protein expression in non-small cell lung cancer. ". Pathol Res Pract. 2015. PMID 26554593.
• "Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. ". Mol Cell. 2017. PMID 28689658.
• "Gankyrin promotes the proliferation of gastric cancer and is associated with chemosensitivity. ". Tumour Biol. 2017. PMID 28653901.
• "Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.". Sci Rep. 2016. PMID 27046077.