PSMC5

PSMC5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KRK, 3KW6
Dynodwyr
Cyfenwau	PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6
Dynodwyr allanol	OMIM: 601681 HomoloGene: 2098 GeneCards: PSMC5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • thyrotropin-releasing hormone receptor binding • GO:0001948, GO:0016582 protein binding • ATP binding • signaling receptor binding • hydrolase activity • ATPase activity • TBP-class protein binding • transcription factor binding • proteasome-activating activity Cydrannau o'r gell • cytosol • proteasome regulatory particle, base subcomplex • blood microparticle • bilen • proteasome regulatory particle • nucleoplasm • inclusion body • extracellular exosome • GO:0016023 cytoplasmic vesicle • proteasome complex • cytosolic proteasome complex • cytoplasm • proteasome accessory complex • cnewyllyn cell • nuclear proteasome complex • postsynapse Prosesau biolegol • positive regulation of RNA polymerase II transcription preinitiation complex assembly • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • positive regulation of inclusion body assembly • MAPK cascade • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • Fc-epsilon receptor signaling pathway • GO:0044257 protein catabolic process • NIK/NF-kappaB signaling • ubiquitin-dependent ERAD pathway • negative regulation of programmed cell death • anaphase-promoting complex-dependent catabolic process • GO:0045996 negative regulation of transcription, DNA-templated • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • positive regulation of proteasomal protein catabolic process • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • modulation of chemical synaptic transmission • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • post-translational protein modification • regulation of hematopoietic stem cell differentiation • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5705	n/a
Ensembl	ENSG00000087191	n/a
UniProt	P62195	n/a
RefSeq (mRNA)	NM_001199163 NM_002805	n/a
RefSeq (protein)	NP_001186092 NP_002796	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMC5 yw PSMC5 a elwir hefyd yn Proteasome 26S subunit, ATPase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMC5.

• S8
• p45
• SUG1
• SUG-1
• TBP10
• TRIP1
• p45/SUG

Llyfryddiaeth

• "Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. ". Mol Cancer Ther. 2006. PMID 16432160.
• "TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation. ". Respir Res. 2014. PMID 24528651.
• "Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells. ". Biochem Biophys Res Commun. 2016. PMID 26592665.
• "The Xanthomonas campestris type III effector XopJ proteolytically degrades proteasome subunit RPT6. ". Plant Physiol. 2015. PMID 25739698.
• "Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.". Immunol Lett. 2012. PMID 22771340.