PSMB5

PSMB5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R3O, 4R67, 5A0Q
Dynodwyr
Cyfenwau	PSMB5, LMPX, MB1, proteasome subunit beta 5, X, proteasome 20S subunit beta 5
Dynodwyr allanol	OMIM: 600306 HomoloGene: 55690 GeneCards: PSMB5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • threonine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • cytoplasm • cytosol • centrosome • nucleoplasm • proteasome complex • extracellular exosome • cnewyllyn cell • proteasome core complex • proteasome core complex, beta-subunit complex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • GO:0001306 response to oxidative stress • proteolysis • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • GO:0022415 viral process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • proteasomal protein catabolic process • proteasomal ubiquitin-independent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5693	n/a
Ensembl	ENSG00000100804	n/a
UniProt	P28074	n/a
RefSeq (mRNA)	NM_001130725 NM_001144932 NM_002797	n/a
RefSeq (protein)	NP_001124197 NP_001138404 NP_002788	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB5 yw PSMB5 a elwir hefyd yn Proteasome subunit beta 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB5.

• X
• MB1
• LMPX

Llyfryddiaeth

• "Proteasome subunit β5t expression in cervical ectopic thymoma. ". J Clin Pathol. 2012. PMID 22523338.
• "Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. ". Leuk Res. 2012. PMID 21978467.
• "Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells. ". J Exp Clin Cancer Res. 2017. PMID 28143565.
• "Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression. ". Biochem Biophys Res Commun. 2014. PMID 24393841.
• "[Expression of proteasome β5 subunit in human atherosclerotic plaque].". Zhonghua Yi Xue Za Zhi. 2012. PMID 22781773.