PSMA4

PSMA4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R3O, 4R67, 1IRU, 5A0Q
Dynodwyr
Cyfenwau	PSMA4, HC9, HsT17706, PSC9, proteasome subunit alpha 4, proteasome 20S subunit alpha 4
Dynodwyr allanol	OMIM: 176846 HomoloGene: 2083 GeneCards: PSMA4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • threonine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • intracellular membrane-bounded organelle • P-body • nucleoplasm • proteasome complex • extracellular exosome • cnewyllyn cell • proteasome core complex • cytoplasm • cytosol • proteasome core complex, alpha-subunit complex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • ubiquitin-dependent protein catabolic process • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • proteolysis • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • GO:0022415 viral process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • proteasomal protein catabolic process • proteasomal ubiquitin-independent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5685	n/a
Ensembl	ENSG00000041357	n/a
UniProt	P25789	n/a
RefSeq (mRNA)	NM_002789 NM_001102667 NM_001102668 NM_001330673 NM_001330675 NM_001330676	n/a
RefSeq (protein)	NP_001096137 NP_001096138 NP_001317602 NP_001317604 NP_001317605 NP_002780	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMA4 yw PSMA4 a elwir hefyd yn Proteasome subunit alpha type a Proteasome subunit alpha 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMA4.

• HC9
• PSC9
• HsT17706

Llyfryddiaeth

• "Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. ". Proc Natl Acad Sci U S A. 2009. PMID 19581590.
• "Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state. ". Virology. 1998. PMID 9875328.
• "Association of PSMA4 polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population. ". Clin Transl Oncol. 2015. PMID 25744645.
• "Gene expression induced by BO-653, probucol and BHQ in human endothelial cells. ". J Atheroscler Thromb. 2000. PMID 11521686.
• "Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol.". Biochem J. 1996. PMID 8687380.