PSMA1

PSMA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R3O, 4R67, 1IRU, 5A0Q
Dynodwyr
Cyfenwau	PSMA1, HC2, HEL-S-275, NU, PROS30, Proteasome (prosome, macropain) subunit, alpha 1, proteasome subunit alpha 1, proteasome 20S subunit alpha 1
Dynodwyr allanol	OMIM: 602854 HomoloGene: 2080 GeneCards: PSMA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • RNA binding • threonine-type endopeptidase activity • hydrolase activity • lipopolysaccharide binding Cydrannau o'r gell • cytoplasm • polysome • cytosol • centrosome • nucleoplasm • proteasome complex • extracellular exosome • cnewyllyn cell • proteasome core complex • proteasome core complex, alpha-subunit complex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • ubiquitin-dependent protein catabolic process • regulation of mRNA stability • immune system process • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • proteolysis • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • negative regulation of inflammatory response to antigenic stimulus • proteasomal protein catabolic process • proteasomal ubiquitin-independent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5682	n/a
Ensembl	ENSG00000129084	n/a
UniProt	P25786	n/a
RefSeq (mRNA)	NM_148976 NM_001143937 NM_002786	n/a
RefSeq (protein)	NP_001137409 NP_002777 NP_683877	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMA1 yw PSMA1 a elwir hefyd yn Proteasome subunit alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMA1.

• NU
• HC2
• PROS30
• HEL-S-275

Llyfryddiaeth

• "Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells. ". J Biol Chem. 1992. PMID 1517242.
• "Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. ". Gene. 1992. PMID 1398136.
• "Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. ". PLoS One. 2013. PMID 24040035.
• "Sperm-specific C-terminal processing of the proteasome PSMA1/α6 subunit. ". Biochem Biophys Res Commun. 2011. PMID 21703233.
• "Identical subunit topographies of human and yeast 20S proteasomes.". Arch Biochem Biophys. 1999. PMID 10068451.