PSIP1

PSIP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z9E, 2B4J, 2M16, 2MSR, 2MTN, 2N3A, 3F9K, 3HPG, 3HPH, 3U88, 3ZEH, 4FU6
Dynodwyr
Cyfenwau	PSIP1, DFS70, LEDGF, PAIP, PSIP2, p52, p75, PC4 and SFRS1 interacting protein 1
Dynodwyr allanol	OMIM: 603620 HomoloGene: 13242 GeneCards: PSIP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001105 transcription coactivator activity • chromatin binding • GO:0001948, GO:0016582 protein binding • supercoiled DNA binding • RNA binding Cydrannau o'r gell • cytosol • nuclear periphery • nucleoplasm • nucleolus • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • response to heat • GO:0001306 response to oxidative stress • transcription, DNA-templated • establishment of integrated proviral latency • mRNA 5'-splice site recognition • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0022415 viral process • nuclear transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11168	n/a
Ensembl	ENSG00000164985	n/a
UniProt	O75475	n/a
RefSeq (mRNA)	NM_001128217 NM_021144 NM_033222 NM_001317898 NM_001317900	n/a
RefSeq (protein)	NP_001121689 NP_001304827 NP_001304829 NP_066967 NP_150091	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSIP1 yw PSIP1 a elwir hefyd yn PC4 and SFRS1 interacting protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSIP1.

• p52
• p75
• PAIP
• DFS70
• LEDGF
• PSIP2

Llyfryddiaeth

• "Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individuals. ". PLoS One. 2014. PMID 25047784.
• "Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene. ". PLoS Pathog. 2014. PMID 24604027.
• "PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes. ". Carcinogenesis. 2017. PMID 28633434.
• "Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. ". Oncotarget. 2016. PMID 26840454.
• "LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.". Genes Dev. 2015. PMID 26545813.