PRTN3

PRTN3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FUJ
Dynodwyr
Cyfenwau	PRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
Dynodwyr allanol	OMIM: 177020 HomoloGene: 120934 GeneCards: PRTN3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • enzyme binding • GO:0070122 peptidase activity • serine-type peptidase activity • hydrolase activity • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase activity • signaling receptor binding Cydrannau o'r gell • GO:0005578 extracellular matrix • Cellbilen • extracellular exosome • cytosol • extracellular region • extracellular space • azurophil granule lumen • plasma membrane raft • bilen • membrane raft • collagen-containing extracellular matrix Prosesau biolegol • collagen catabolic process • blood coagulation • negative regulation of phagocytosis • mature conventional dendritic cell differentiation • positive regulation of cell population proliferation • antimicrobial humoral response • neutrophil degranulation • proteolysis • membrane protein ectodomain proteolysis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cell-cell junction maintenance • neutrophil extravasation • ffagocytosis • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5657	n/a
Ensembl	ENSG00000277804 ENSG00000196415	n/a
UniProt	P24158	n/a
RefSeq (mRNA)	NM_002777	n/a
RefSeq (protein)	NP_002768	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRTN3 yw PRTN3 a elwir hefyd yn Proteinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRTN3.

• MBN
• MBT
• NP4
• P29
• PR3
• ACPA
• AGP7
• NP-4
• PR-3
• CANCA
• C-ANCA

Llyfryddiaeth

• "Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis. ". J Immunol. 2017. PMID 29079698.
• "Proteinase 3: the odd one out that became an autoantigen. ". J Leukoc Biol. 2017. PMID 28546501.
• "Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles. ". J Biol Chem. 2016. PMID 26961880.
• "Clinical Implication of Proteinase-3-antineutrophil Cytoplasmic Antibody in Patients with Idiopathic Interstitial Pneumonias. ". Lung. 2016. PMID 26873743.
• "Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population.". Arthritis Res Ther. 2015. PMID 25927497.