PRPF3

PRPF3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X4Q, 3JCR
Dynodwyr
Cyfenwau	PRPF3, pre-mRNA processing factor 3, HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90
Dynodwyr allanol	OMIM: 607301 HomoloGene: 3447 GeneCards: PRPF3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding • RNA binding Cydrannau o'r gell • Cajal body • U4/U6 x U5 tri-snRNP complex • spliceosomal complex • cnewyllyn cell • nucleoplasm • cytosol • nuclear speck • GO:0009327 protein-containing complex • U2-type precatalytic spliceosome Prosesau biolegol • RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • mRNA processing • spliceosomal tri-snRNP complex assembly • RNA splicing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9129	n/a
Ensembl	ENSG00000117360	n/a
UniProt	O43395	n/a
RefSeq (mRNA)	NM_004698 NM_001350529	n/a
RefSeq (protein)	NP_004689 NP_001337458	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRPF3 yw PRPF3 a elwir hefyd yn Pre-mRNA processing factor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRPF3.

• PRP3
• RP18
• HPRP3
• Prp3p
• HPRP3P
• SNRNP90

Llyfryddiaeth

• "SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. ". Nucleic Acids Res. 2017. PMID 28379520.
• "Variable phenotypic expressivity in a Swiss family with autosomal dominant retinitis pigmentosa due to a T494M mutation in the PRPF3 gene. ". Mol Vis. 2010. PMID 20309403.
• "Contribution of the individual subunits of protein kinase CK2 and of hPrp3p to the splicing process. ". Mol Cell Biochem. 2008. PMID 18553058.
• "Mutation in the splicing factor Hprp3p linked to retinitis pigmentosa impairs interactions within the U4/U6 snRNP complex. ". Hum Mol Genet. 2008. PMID 17932117.
• "Mutations in splicing factor PRPF3, causing retinal degeneration, form detrimental aggregates in photoreceptor cells.". Hum Mol Genet. 2007. PMID 17517693.