PROC

PROC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AUT, 1LQV, 3F6U, 3JTC, 4DT7
Dynodwyr
Cyfenwau	PROC, APC, PC, PROC1, THPH3, THPH4, protein C, inactivator of coagulation factors Va and VIIIa
Dynodwyr allanol	OMIM: 612283 HomoloGene: 37288 GeneCards: PROC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • Golgi apparatus • endoplasmic reticulum lumen • extracellular region • Reticwlwm endoplasmig • Golgi lumen • extracellular space Prosesau biolegol • hemostasis • negative regulation of coagulation • negative regulation of blood coagulation • blood coagulation • negative regulation of apoptotic process • positive regulation of establishment of endothelial barrier • proteolysis • endoplasmic reticulum to Golgi vesicle-mediated transport • negative regulation of inflammatory response • liver development • regulation of circulating fibrinogen levels • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5624	n/a
Ensembl	ENSG00000115718	n/a
UniProt	P04070	n/a
RefSeq (mRNA)	NM_000312	n/a
RefSeq (protein)	NP_000303 NP_001362531 NP_001362532 NP_001362533 NP_001362534 NP_001362535 NP_001362536 NP_001362537 NP_001362538 NP_001362539 NP_001362540 NP_001362542	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PROC yw PROC a elwir hefyd yn Protein C, inactivator of coagulation factors Va and VIIIa (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PROC.

• PC
• APC
• PROC1
• THPH3
• THPH4

Llyfryddiaeth

• "Activated protein C inhibits neutrophil extracellular trap formation in vitroand activation in vivo. ". J Biol Chem. 2017. PMID 28408624.
• "[Analysis of phenotypes and genetic mutations in two pedigrees affected with hereditary protein C deficiency]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28186585.
• "The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene. ". Pediatr Blood Cancer. 2017. PMID 28111891.
• "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities). ". Arterioscler Thromb Vasc Biol. 2017. PMID 28082259.
• "Two novel compound heterozygous mutations associated with types I and II protein C deficiency with unusual phenotypes.". Thromb Res. 2016. PMID 27517348.