PRNP

PRNP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2OL9, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NHD, 3NVF, 4DGI, 4E1H, 4E1I,%%s1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2M8T, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NVF, 4DGI, 4E1H, 4E1I, 4KML, 4N9O
Dynodwyr
Cyfenwau	PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
Dynodwyr allanol	OMIM: 176640 HomoloGene: 7904 GeneCards: PRNP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • chaperone binding • transmembrane transporter binding • microtubule binding • ATP-dependent protein binding • metal ion binding • tubulin binding • GO:0001948, GO:0016582 protein binding • identical protein binding • copper ion binding • lamin binding • amyloid-beta binding • protease binding • glycosaminoglycan binding • type 5 metabotropic glutamate receptor binding • type 8 metabotropic glutamate receptor binding • signaling receptor activity • GO:0032403 protein-containing complex binding • cupric ion binding • cuprous ion binding Cydrannau o'r gell • mitochondrial outer membrane • bilen • mitocondria • integral component of membrane • cytoplasm • Golgi apparatus • Cellbilen • cell surface • Reticwlwm endoplasmig • membrane raft • anchored component of membrane • extracellular exosome • cnewyllyn cell • extrinsic component of membrane • cytosol • GO:0097483, GO:0097481 postsynaptic density • inclusion body • dendrite • anchored component of external side of plasma membrane • nuclear membrane • intracellular membrane-bounded organelle • postsynapse Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • negative regulation of interferon-gamma production • response to cadmium ion • negative regulation of calcineurin-NFAT signaling cascade • response to copper ion • negative regulation of apoptotic process • GO:0001306 response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of T cell receptor signaling pathway • regulation of protein localization • negative regulation of activated T cell proliferation • learning or memory • cellular copper ion homeostasis • cellular response to copper ion • cell cycle • metabolaeth • negative regulation of interleukin-17 production • protein homooligomerization • negative regulation of interleukin-2 production • regulation of potassium ion transmembrane transport • long-term memory • positive regulation of cell death • negative regulation of protein processing • protein destabilization • activation of protein kinase activity • calcium-mediated signaling using intracellular calcium source • GO:0048553 negative regulation of catalytic activity • positive regulation of neuron apoptotic process • regulation of peptidyl-tyrosine phosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • positive regulation of protein targeting to membrane • dendritic spine maintenance • negative regulation of long-term synaptic potentiation • regulation of glutamate receptor signaling pathway • positive regulation of neuron death • negative regulation of amyloid-beta formation • regulation of intracellular calcium activated chloride channel activity • negative regulation of dendritic spine maintenance • negative regulation of amyloid precursor protein catabolic process • positive regulation of protein localization to plasma membrane • response to amyloid-beta • cellular response to amyloid-beta • regulation of calcium ion import across plasma membrane • neuron projection maintenance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5621	n/a
Ensembl	ENSG00000171867	n/a
UniProt	P04156	n/a
RefSeq (mRNA)	NM_183079 NM_000311 NM_001080121 NM_001080122 NM_001080123 NM_001271561	n/a
RefSeq (protein)	NP_000302 NP_001073590 NP_001073591 NP_001073592 NP_001258490 NP_898902 NP_000302.1 NP_001073590.1 NP_001073591.1 NP_001073592.1 NP_898902.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRNP yw PRNP a elwir hefyd yn Major prion protein a Prion protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRNP.

• CJD
• GSS
• PrP
• ASCR
• KURU
• PRIP
• PrPc
• CD230
• AltPrP
• p27-30
• PrP27-30
• PrP33-35C

Llyfryddiaeth

• "Human stem cell-derived astrocytes replicate human prions in a PRNPgenotype-dependent manner. ". J Exp Med. 2017. PMID 29141869.
• "Identification of the internal ribosome entry sites (IRES) of prion protein gene. ". Int J Biochem Cell Biol. 2017. PMID 29107182.
• "The Role of Shed PrPc in the Neuropathogenesis of HIV Infection. ". J Immunol. 2017. PMID 28533442.
• "Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay. ". J Biol Chem. 2017. PMID 28341739.
• "Prion-like proteins and their computational identification in proteomes.". Expert Rev Proteomics. 2017. PMID 28271922.