PRMT3

PRMT3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Dynodwyr
Cyfenwau	PRMT3, HRMT1L3, protein arginine methyltransferase 3
Dynodwyr allanol	OMIM: 603190 HomoloGene: 24255 GeneCards: PRMT3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • GO:0001948, GO:0016582 protein binding • protein-arginine N-methyltransferase activity • nucleic acid binding • histone-arginine N-methyltransferase activity • protein-arginine omega-N asymmetric methyltransferase activity • ribosome binding Cydrannau o'r gell • ribosom • cytoplasm • cytosol • cnewyllyn cell Prosesau biolegol • methylation • negative regulation of protein ubiquitination • peptidyl-arginine N-methylation • protein methylation • GO:0009373 regulation of transcription, DNA-templated • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine • histone arginine methylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10196	n/a
Ensembl	ENSG00000185238	n/a
UniProt	O60678	n/a
RefSeq (mRNA)	NM_001145166 NM_001145167 NM_005788	n/a
RefSeq (protein)	NP_001138638 NP_001138639 NP_005779	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRMT3 yw PRMT3 a elwir hefyd yn Protein arginine methyltransferase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRMT3.

• HRMT1L3

Llyfryddiaeth

• "Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. ". Mol Biosyst. 2011. PMID 21866297.
• "Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3). ". Biochim Biophys Acta. 2011. PMID 21059412.
• "Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. ". ACS Chem Biol. 2014. PMID 24320160.
• "Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. ". J Med Chem. 2013. PMID 23445220.
• "An allosteric inhibitor of protein arginine methyltransferase 3.". Structure. 2012. PMID 22795084.