PRMT2

PRMT2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X2P
Dynodwyr
Cyfenwau	PRMT2, HRMT1L1, protein arginine methyltransferase 2
Dynodwyr allanol	OMIM: 601961 HomoloGene: 55587 GeneCards: PRMT2
EC number	2.1.1.321
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • histone methyltransferase activity • protein homodimerization activity • progesterone receptor binding • GO:0001105 transcription coactivator activity • signal transducer activity • thyroid hormone receptor binding • GO:0001948, GO:0016582 protein binding • androgen receptor binding • peroxisome proliferator activated receptor binding • retinoic acid receptor binding • estrogen receptor binding • protein-arginine N-methyltransferase activity • histone-arginine N-methyltransferase activity • protein-arginine omega-N asymmetric methyltransferase activity • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • Rb-E2F complex • nucleoplasm • nucleolus • cnewyllyn cell Prosesau biolegol • developmental cell growth • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • methylation • positive regulation of apoptotic process • regulation of androgen receptor signaling pathway • histone methylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • GO:0072468 signal transduction • protein methylation • histone arginine methylation • peptidyl-arginine N-methylation • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine • GO:0009373 regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3275	n/a
Ensembl	ENSG00000160310	n/a
UniProt	P55345	n/a
RefSeq (mRNA)	NM_001242864 NM_001242865 NM_001242866 NM_001286676 NM_001286677 NM_001286678 NM_001535 NM_206962	n/a
RefSeq (protein)	NP_001229793 NP_001229794 NP_001229795 NP_001273605 NP_001273606 NP_001273607 NP_001526 NP_996845	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRMT2 yw PRMT2 a elwir hefyd yn Protein arginine methyltransferase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRMT2.

• HRMT1L1

Llyfryddiaeth

• "Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer. ". Gene. 2011. PMID 21820040.
• "Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. ". Mamm Genome. 1997. PMID 9196002.
• "PRMT2 and RORγ expression are associated with breast cancer survival outcomes. ". Mol Endocrinol. 2014. PMID 24911119.
• "Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein. ". Oncogene. 2014. PMID 24292672.
• "Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.". FEBS J. 2012. PMID 22093364.