PRMT1

PRMT1
Dynodwyr
Cyfenwau	PRMT1, ANM1, HCP1, HRMT1L2, IR1B4, protein arginine methyltransferase 1
Dynodwyr allanol	OMIM: 602950 HomoloGene: 21477 GeneCards: PRMT1
EC number	2.1.1.321
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • histone methyltransferase activity • transferase activity • histone methyltransferase activity (H4-R3 specific) • methyl-CpG binding • mitogen-activated protein kinase p38 binding • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • N-methyltransferase activity • protein-arginine omega-N asymmetric methyltransferase activity • RNA binding • protein methyltransferase activity • protein-arginine N-methyltransferase activity • histone-arginine N-methyltransferase activity • GO:0016275 protein-arginine omega-N monomethyltransferase activity • S-adenosyl-L-methionine binding Cydrannau o'r gell • cytoplasm • nucleoplasm • methylosome • cnewyllyn cell • cytosol Prosesau biolegol • positive regulation of p38MAPK cascade • positive regulation of hemoglobin biosynthetic process • histone H4-R3 methylation • positive regulation of erythrocyte differentiation • negative regulation of megakaryocyte differentiation • cell surface receptor signaling pathway • methylation • peptidyl-arginine methylation • histone methylation • neuron projection development • peptidyl-arginine N-methylation • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:0009373 regulation of transcription, DNA-templated • protein methylation • positive regulation of cell population proliferation • regulation of megakaryocyte differentiation • in utero embryonic development • histone arginine methylation • protein homooligomerization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3276	n/a
Ensembl	ENSG00000126457	n/a
UniProt	Q99873	n/a
RefSeq (mRNA)	NM_001207042 NM_001536 NM_198318 NM_198319	n/a
RefSeq (protein)	NP_001193971 NP_001527 NP_938074	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRMT1 yw PRMT1 a elwir hefyd yn Protein arginine methyltransferase 1 a Protein arginine N-methyltransferase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRMT1.

• ANM1
• HCP1
• IR1B4
• HRMT1L2

Llyfryddiaeth

• "Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells. ". Tumour Biol. 2017. PMID 28231732.
• "Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics. ". Bioorg Med Chem. 2016. PMID 27545444.
• "Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. ". Sci Rep. 2016. PMID 26911452.
• "Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. ". Acta Neuropathol. 2016. PMID 26895297.
• "Effect of protein arginine methyltransferase-1 inhibition on hypoxia-induced vasoconstriction.". Med Hypotheses. 2015. PMID 26527496.