PRKRA

PRKRA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DIX
Dynodwyr
Cyfenwau	PRKRA, DYT16, PACT, RAX, HSD14, protein activator of interferon induced protein kinase EIF2AK2
Dynodwyr allanol	OMIM: 603424 HomoloGene: 2738 GeneCards: PRKRA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • double-stranded RNA binding • GO:0010577 enzyme activator activity • RNA binding • pre-miRNA binding Cydrannau o'r gell • cytoplasm • bilen • intracellular anatomical structure • nucleoplasm • perinuclear region of cytoplasm • cytosol • RISC-loading complex Prosesau biolegol • skeletal system morphogenesis • response to virus • outer ear morphogenesis • pre-miRNA processing • protein phosphorylation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • middle ear morphogenesis • cellular response to oxidative stress • positive regulation of intrinsic apoptotic signaling pathway • negative regulation of cell population proliferation • production of miRNAs involved in gene silencing by miRNA • GO:0048554 positive regulation of catalytic activity • protein stabilization • GO:0061715 miRNA metabolic process • GO:0070919 production of siRNA involved in RNA interference • gene silencing • GO:0022415 viral process • ear development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8575	n/a
Ensembl	ENSG00000180228	n/a
UniProt	O75569	n/a
RefSeq (mRNA)	NM_001139517 NM_001139518 NM_001316362 NM_003690	n/a
RefSeq (protein)	NP_001132989 NP_001132990 NP_001303291 NP_003681	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKRA yw PRKRA a elwir hefyd yn Protein activator of interferon induced protein kinase EIF2AK2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKRA.

• RAX
• PACT
• DYT16
• HSD14

Llyfryddiaeth

• "Mutational analysis of PACT gene in Chinese patients with microtia. ". Am J Med Genet A. 2011. PMID 21595004.
• "Biochemical analysis of PKR activation by PACT. ". Biochemistry. 2009. PMID 19580324.
• "Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus. ". J Virol. 2015. PMID 26355092.
• "DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family. ". Mov Disord. 2014. PMID 25142429.
• "PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator.". Genes Dev. 2014. PMID 24939934.