PRKG1

PRKG1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZXA, 3OCP, 3OD0, 3OGJ, 4KU7, 4KU8, 4QX5, 4QXK, 4R4L, 4R4M, 4Z07
Dynodwyr
Cyfenwau	PRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
Dynodwyr allanol	OMIM: 176894 HomoloGene: 55964 GeneCards: PRKG1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • calcium channel regulator activity • cGMP binding • kinase activity • GO:0001948, GO:0016582 protein binding • catalytic activity • ATP binding • protein serine/threonine kinase activity • cGMP-dependent protein kinase activity • identical protein binding • protein kinase activity Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • Cellbilen Prosesau biolegol • negative regulation of smooth muscle contraction • phosphorylation • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • dendrite development • neuron migration • negative regulation of platelet aggregation • cGMP-mediated signaling • relaxation of vascular associated smooth muscle • forebrain development • metabolaeth • actin cytoskeleton organization • GO:0072468 signal transduction • protein phosphorylation • negative regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5592	n/a
Ensembl	ENSG00000185532	n/a
UniProt	Q13976	n/a
RefSeq (mRNA)	NM_001098512 NM_006258 NM_001374781 NM_001374782	n/a
RefSeq (protein)	NP_001091982 NP_006249 NP_001361710 NP_001361711	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKG1 yw PRKG1 a elwir hefyd yn cGMP-dependent protein kinase 1 a Protein kinase, cGMP-dependent, type I (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q11.23-q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKG1.

• PKG
• cGK
• AAT8
• cGK1
• cGKI
• cGK*1
• PRKG1B
• PRKGR1B
• cGKI-BETA
• cGKI-alpha

Llyfryddiaeth

• "Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. ". Biochemistry. 2015. PMID 26132214.
• "Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design. ". Biochemistry. 2014. PMID 25271401.
• "Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. ". Redox Biol. 2017. PMID 27978504.
• "PRKG1 and genetic diagnosis of early-onset thoracic aortic disease. ". Eur J Clin Invest. 2016. PMID 27442293.
• "Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).". J Biol Chem. 2015. PMID 26370085.