PRKD2

PRKD2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2COA, 3BGM, 4NNX, 4NNY
Dynodwyr
Cyfenwau	PRKD2, PKD2, nPKC-D2, HSPC187, protein kinase D2
Dynodwyr allanol	OMIM: 607074 HomoloGene: 9516 GeneCards: PRKD2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • protein serine/threonine kinase activity • protein kinase C binding Cydrannau o'r gell • cytoplasm • Golgi apparatus • bilen • nucleoplasm • cnewyllyn cell • cytosol • Cellbilen • intracellular anatomical structure Prosesau biolegol • positive regulation of vascular endothelial growth factor receptor signaling pathway • GO:0007243 intracellular signal transduction • positive regulation of endothelial cell proliferation • adaptive immune response • phosphorylation • immune system process • endothelial tube morphogenesis • positive regulation of fibroblast growth factor receptor signaling pathway • positive regulation of T cell receptor signaling pathway • positive regulation of endothelial cell chemotaxis • positive regulation of DNA-binding transcription factor activity • marwolaeth celloedd • protein kinase D signaling • GO:0010740 positive regulation of intracellular signal transduction • positive regulation of peptidyl-serine phosphorylation • positive regulation of angiogenesis • positive regulation of endothelial cell migration • protein phosphorylation • positive regulation of histone deacetylase activity • positive regulation of CREB transcription factor activity • vascular endothelial growth factor receptor signaling pathway • cell adhesion • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • angiogenesis • positive regulation of interleukin-8 production • positive regulation of blood vessel endothelial cell migration • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • protein autophosphorylation • cellular response to vascular endothelial growth factor stimulus • T cell receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell adhesion • sphingolipid biosynthetic process • GO:0035404 peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	25865	n/a
Ensembl	ENSG00000105287	n/a
UniProt	Q9BZL6	n/a
RefSeq (mRNA)	NM_001079880 NM_001079881 NM_001079882 NM_016457	n/a
RefSeq (protein)	NP_001073349 NP_001073350 NP_001073351 NP_057541	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKD2 yw PRKD2 a elwir hefyd yn Serine/threonine-protein kinase D2 a Protein kinase D2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKD2.

• PKD2
• HSPC187
• nPKC-D2

Llyfryddiaeth

• "Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. ". Gut. 2010. PMID 20732914.
• "Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration. ". Arterioscler Thromb Vasc Biol. 2009. PMID 19520973.
• "Protein kinase D2 silencing reduced motility of doxorubicin-resistant MCF7 cells. ". Tumour Biol. 2015. PMID 25874490.
• "Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways. ". Neuro Oncol. 2014. PMID 24463355.
• "Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.". Exp Cell Res. 2013. PMID 23562655.