PRKCI

PRKCI
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8
Dynodwyr
Cyfenwau	PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota
Dynodwyr allanol	OMIM: 600539 HomoloGene: 37667 GeneCards: PRKCI
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • protein domain specific binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • phospholipid binding • ATP binding Cydrannau o'r gell • cytosol • endosome • bilen • bicellular tight junction • microtubule cytoskeleton • Golgi membrane • Cellbilen • apical part of cell • Schmidt-Lanterman incisure • apical plasma membrane • cell leading edge • intercellular bridge • extracellular exosome • cnewyllyn cell • cytoplasm • nucleoplasm • GO:0009327 protein-containing complex • Schaffer collateral - CA1 synapse • glutamatergic synapse Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of glucose import • establishment of apical/basal cell polarity • GO:0007243 intracellular signal transduction • response to interleukin-1 • phosphorylation • Golgi vesicle budding • actin filament organization • protein targeting to membrane • negative regulation of glial cell apoptotic process • response to peptide hormone • negative regulation of apoptotic process • secretion • protein phosphorylation • positive regulation of endothelial cell apoptotic process • positive regulation of NF-kappaB transcription factor activity • cytoskeleton organization • establishment or maintenance of epithelial cell apical/basal polarity • bicellular tight junction assembly • positive regulation of neuron projection development • cellular response to insulin stimulus • eye photoreceptor cell development • membrane organization • positive regulation of glial cell proliferation • cell migration • vesicle-mediated transport • cell-cell junction organization • GO:0035404 peptidyl-serine phosphorylation • positive regulation of protein localization to plasma membrane • positive regulation of Notch signaling pathway • regulation of postsynaptic membrane neurotransmitter receptor levels Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5584	n/a
Ensembl	ENSG00000163558	n/a
UniProt	P41743	n/a
RefSeq (mRNA)	NM_002740	n/a
RefSeq (protein)	NP_002731	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCI yw PRKCI a elwir hefyd yn Protein kinase C iota (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q26.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCI.

• PKCI
• DXS1179E
• nPKC-iota

Llyfryddiaeth

• "Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis. ". Int J Gynecol Pathol. 2016. PMID 26535980.
• "Association of polymorphisms in PRKCI gene and risk of prostate cancer in a sample of Iranian Population. ". Cell Mol Biol (Noisy-le-grand). 2015. PMID 26475383.
• "aPKC-ι/P-Sp1/Snail signaling induces epithelial-mesenchymal transition and immunosuppression in cholangiocarcinoma. ". Hepatology. 2017. PMID 28574228.
• "PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma. ". Tumour Biol. 2016. PMID 27481515.
• "Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation.". Dev Biol. 2016. PMID 27312576.