PRKAR2B

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PRKAR2B
Protein PRKAR2B PDB 1cx4.png
Strwythurau
PDBOrthologau:PDBe RCSB
Dynodwyr
CyfenwauPRKAR2B, PRKAR2, RII-BETA, protein kinase cAMP-dependent type II regulatory subunit beta
Dynodwyr allanolOMIM: 176912 MGI: 97760 HomoloGene: 37666 GeneCards: PRKAR2B
Patrwm RNA pattern
PBB GE PRKAR2B 203680 at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002736

NM_011158
NM_001364407
NM_001364408

RefSeq (protein)

NP_002727
NP_002727.2

NP_035288
NP_001351336
NP_001351337

Lleoliad (UCSC)n/aChr : 31.96 – 32.06 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAR2B yw PRKAR2B a elwir hefyd yn Protein kinase, cAMP-dependent, regulatory, type II, beta, isoform CRA_a a Protein kinase cAMP-dependent type II regulatory subunit beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q22.3.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAR2B.

  • PRKAR2
  • RII-BETA

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells. ". J Immunol. 2003. PMID 14500661.
  • "Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A. ". J Cell Sci. 2001. PMID 11591815.
  • "Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain. ". Hum Psychopharmacol. 2014. PMID 24737441.
  • "Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. ". J Biol Chem. 2008. PMID 18544528.
  • "Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.". Eur J Endocrinol. 2008. PMID 18505904.

Cyfeiriadau[golygu | golygu cod y dudalen]

  1. 1.0 1.1 1.2 GRCm38: Ensembl release 89: ENSMUSG00000002997 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. PRKAR2B - Cronfa NCBI