PRKAR2B

PRKAR2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3TNP, 3TNQ, 4WBB, 4X6Q
Dynodwyr
Cyfenwau	PRKAR2B, PRKAR2, RII-BETA, protein kinase cAMP-dependent type II regulatory subunit beta
Dynodwyr allanol	OMIM: 176912 HomoloGene: 37666 GeneCards: PRKAR2B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein domain specific binding • protein kinase A catalytic subunit binding • cAMP binding • cAMP-dependent protein kinase regulator activity • cAMP-dependent protein kinase inhibitor activity • protein kinase binding • ubiquitin protein ligase binding • GO:0001948, GO:0016582 protein binding • 3',5'-cyclic-GMP phosphodiesterase activity • kinase activity Cydrannau o'r gell • cytoplasm • cytosol • centrosome • bilen • Cellbilen • dendritic spine • ciliary base • dendritic shaft • neuronal cell body • dendrite • perinuclear region of cytoplasm • mitochondrial inner membrane • membrane raft • cAMP-dependent protein kinase complex • extracellular exosome • postsynapse • glutamatergic synapse Prosesau biolegol • regulation of protein phosphorylation • activation of protein kinase A activity • GO:0007243 intracellular signal transduction • response to antipsychotic drug • cellular response to glucagon stimulus • blood coagulation • learning • negative regulation of cAMP-dependent protein kinase activity • fatty acid metabolic process • G2/M transition of mitotic cell cycle • response to clozapine • renal water homeostasis • regulation of protein kinase activity • ciliary basal body-plasma membrane docking • regulation of G2/M transition of mitotic cell cycle • cGMP-mediated signaling • modulation of chemical synaptic transmission • phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5577	n/a
Ensembl	ENSG00000005249 ENSG00000284096	n/a
UniProt	P31323	n/a
RefSeq (mRNA)	NM_002736	n/a
RefSeq (protein)	NP_002727 NP_002727.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAR2B yw PRKAR2B a elwir hefyd yn Protein kinase, cAMP-dependent, regulatory, type II, beta, isoform CRA_a a Protein kinase cAMP-dependent type II regulatory subunit beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAR2B.

• PRKAR2
• RII-BETA

Llyfryddiaeth

• "Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells. ". J Immunol. 2003. PMID 14500661.
• "Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A. ". J Cell Sci. 2001. PMID 11591815.
• "Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain. ". Hum Psychopharmacol. 2014. PMID 24737441.
• "Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. ". J Biol Chem. 2008. PMID 18544528.
• "Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.". Eur J Endocrinol. 2008. PMID 18505904.