PRKAR2A

PRKAR2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IZX, 2KYG, 4ZP3
Dynodwyr
Cyfenwau	PRKAR2A, PKR2, PRKAR2, protein kinase cAMP-dependent type II regulatory subunit alpha
Dynodwyr allanol	OMIM: 176910 HomoloGene: 3064 GeneCards: PRKAR2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein kinase A catalytic subunit binding • cAMP binding • GO:0001948, GO:0016582 protein binding • cAMP-dependent protein kinase regulator activity • cAMP-dependent protein kinase inhibitor activity • ubiquitin protein ligase binding • protein domain specific binding • 3',5'-cyclic-GMP phosphodiesterase activity Cydrannau o'r gell • cytoplasm • cytosol • centrosome • bilen • focal adhesion • plasma membrane raft • Cellbilen • ciliary base • nucleotide-activated protein kinase complex • extracellular exosome • GO:0035085 axoneme • cAMP-dependent protein kinase complex • GO:0009327 protein-containing complex Prosesau biolegol • regulation of protein phosphorylation • activation of protein kinase A activity • GO:0007243 intracellular signal transduction • cellular response to glucagon stimulus • blood coagulation • negative regulation of cAMP-dependent protein kinase activity • renal water homeostasis • cGMP-mediated signaling • binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5576	n/a
Ensembl	ENSG00000114302	n/a
UniProt	P13861	n/a
RefSeq (mRNA)	NM_004157 NM_001321982 NM_001321983 NM_001321989	n/a
RefSeq (protein)	NP_001308911 NP_001308912 NP_001308918 NP_004148	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAR2A yw PRKAR2A a elwir hefyd yn cAMP-dependent protein kinase type II-alpha regulatory subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAR2A.

• PKR2
• PRKAR2

Llyfryddiaeth

• "Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme. ". J Clin Endocrinol Metab. 2003. PMID 12727975.
• "Endosome-to-Golgi transport is regulated by protein kinase A type II alpha. ". J Biol Chem. 2003. PMID 12419802.
• "Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer. ". Oncotarget. 2015. PMID 26372733.
• "Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. ". J Biol Chem. 2014. PMID 24753254.
• "Anchoring of protein kinase A-regulatory subunit IIalpha to subapically positioned centrosomes mediates apical bile canalicular lumen development in response to oncostatin M but not cAMP.". Mol Biol Cell. 2007. PMID 17494870.