PRKAR1A

PRKAR1A
Dynodwyr
Cyfenwau	PRKAR1A, ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1, protein kinase cAMP-dependent type I regulatory subunit alpha
Dynodwyr allanol	OMIM: 188830 HomoloGene: 37664 GeneCards: PRKAR1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein kinase A catalytic subunit binding • cAMP binding • GO:0001948, GO:0016582 protein binding • cAMP-dependent protein kinase regulator activity • cAMP-dependent protein kinase inhibitor activity • ubiquitin protein ligase binding • protein domain specific binding • 3',5'-cyclic-GMP phosphodiesterase activity • kinase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • plasma membrane raft • neuromuscular junction • Cellbilen • ciliary base • nucleotide-activated protein kinase complex • immunological synapse • cAMP-dependent protein kinase complex • GO:0035085 axoneme • GO:0009327 protein-containing complex • synapse • glutamatergic synapse Prosesau biolegol • regulation of protein phosphorylation • activation of protein kinase A activity • GO:0007243 intracellular signal transduction • negative regulation of protein kinase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to glucagon stimulus • mesoderm formation • blood coagulation • female meiotic nuclear division • negative regulation of meiotic nuclear division • cardiac muscle cell proliferation • negative regulation of cAMP-dependent protein kinase activity • negative regulation of activated T cell proliferation • heart development • renal water homeostasis • regulation of protein kinase activity • sarcomere organization • cGMP-mediated signaling • phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5573	n/a
Ensembl	ENSG00000108946	n/a
UniProt	P10644	n/a
RefSeq (mRNA)	NM_001276289 NM_001276290 NM_001278433 NM_002734 NM_212471 NM_212472 NM_001369389 NM_001369390	n/a
RefSeq (protein)	NP_001263218 NP_001263219 NP_001265362 NP_002725 NP_997636 NP_997637 NP_001356318 NP_001356319 NP_001263218.1 NP_001265362.1 NP_002725.1 NP_997636.1 NP_997637.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAR1A yw PRKAR1A a elwir hefyd yn Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAR1A.

• CAR
• CNC
• CNC1
• PKR1
• TSE1
• ADOHR
• PPNAD1
• PRKAR1
• ACRDYS1

Llyfryddiaeth

• "Identification of a novel mutation of the PRKAR1A gene in a patient with Carney complex with significant osteoporosis and recurrent fractures. ". Hormones (Athens). 2016. PMID 27377598.
• "Association of Carney Complex with an Intronic Splice Site Mutation in the PRKAR1A Gene. ". Horm Metab Res. 2016. PMID 26788925.
• "Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. ". Biochem J. 2017. PMID 28583991.
• "Electrostatic Switch Function in the Mechanism of Protein Kinase A Iα Activation: Results of the Molecular Dynamics Simulation. ". Biomed Res Int. 2017. PMID 28367443.
• "Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.". Biochemistry. 2017. PMID 28221775.