PRKAB1

PRKAB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4CFE, 4CFF, 5EZV, 4ZHX,%%s4ZHX, 5EZV
Dynodwyr
Cyfenwau	PRKAB1, AMPK, HAMPKb, protein kinase AMP-activated non-catalytic subunit beta 1
Dynodwyr allanol	OMIM: 602740 HomoloGene: 38160 GeneCards: PRKAB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase activity • AMP-activated protein kinase activity • GO:0001948, GO:0016582 protein binding • protein kinase binding • kinase activity Cydrannau o'r gell • cytosol • nucleotide-activated protein kinase complex • cnewyllyn cell • nucleoplasm • GO:0009327 protein-containing complex • cytoplasm Prosesau biolegol • protein heterooligomerization • lipid metabolism • fatty acid metabolic process • protein phosphorylation • GO:1901313 positive regulation of gene expression • fatty acid biosynthetic process • GO:0048552 regulation of catalytic activity • macroautophagy • nail development • GO:0072468 signal transduction • positive regulation of cold-induced thermogenesis • regulation of macroautophagy • regulation of signal transduction by p53 class mediator • phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5564	n/a
Ensembl	ENSG00000111725	n/a
UniProt	Q9Y478	n/a
RefSeq (mRNA)	NM_006253	n/a
RefSeq (protein)	NP_006244 NP_006244.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAB1 yw PRKAB1 a elwir hefyd yn Protein kinase, AMP-activated, beta 1 non-catalytic subunit, isoform CRA_a a Protein kinase AMP-activated non-catalytic subunit beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAB1.

• AMPK
• HAMPKb

Llyfryddiaeth

• "AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. ". Cell Signal. 2011. PMID 21554950.
• "Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics. ". Oncol Rep. 2011. PMID 21271224.
• "Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer. ". Mol Cancer. 2014. PMID 24602453.
• "Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. ". J Lipid Res. 2012. PMID 22323564.
• "AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases.". Biochim Biophys Acta. 2012. PMID 22001850.