PRKAA2

PRKAA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H6D, 2LTU, 2YZA, 3AQV, 4CFE, 4CFF, 4ZHX, 5EZV
Dynodwyr
Cyfenwau	PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2
Dynodwyr allanol	OMIM: 600497 HomoloGene: 4551 GeneCards: PRKAA2
EC number	2.7.11.27
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • [acetyl-CoA carboxylase kinase activity] • AMP-activated protein kinase activity • histone serine kinase activity • chromatin binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] • protein serine/threonine/tyrosine kinase activity • ATP binding Cydrannau o'r gell • cytoplasm • cytosol • nucleoplasm • nucleotide-activated protein kinase complex • cnewyllyn cell • Golgi apparatus • nuclear speck • cytoplasmic stress granule • axon • dendrite • neuronal cell body Prosesau biolegol • carnitine shuttle • steroid metabolic process • GO:0007243 intracellular signal transduction • cellular response to glucose starvation • sterol biosynthetic process • lipid biosynthetic process • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • positive regulation of autophagy • phosphorylation • proses rythmig • lipid metabolism • response to stress • negative regulation of apoptotic process • cholesterol metabolic process • Wnt signaling pathway • regulation of fatty acid biosynthetic process • fatty acid metabolic process • transcription, DNA-templated • cellular response to prostaglandin E stimulus • autophagy • protein phosphorylation • negative regulation of TOR signaling • positive regulation of macroautophagy • fatty acid biosynthetic process • fatty acid homeostasis • regulation of circadian rhythm • cellular response to nutrient levels • regulation of gene expression • cholesterol biosynthetic process • response to muscle activity • positive regulation of glycolytic process • macroautophagy • GO:0072468 signal transduction • steroid biosynthetic process • regulation of signal transduction by p53 class mediator • regulation of macroautophagy • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • negative regulation of gene expression • cellular response to oxidative stress • regulation of stress granule assembly • regulation of microtubule cytoskeleton organization • cellular response to calcium ion • cellular response to glucose stimulus • energy homeostasis • positive regulation of protein localization • negative regulation of tubulin deacetylation • positive regulation of peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5563	n/a
Ensembl	ENSG00000162409	n/a
UniProt	P54646	n/a
RefSeq (mRNA)	NM_006252	n/a
RefSeq (protein)	NP_006243	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAA2 yw PRKAA2 a elwir hefyd yn Protein kinase AMP-activated catalytic subunit alpha 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAA2.

• AMPK
• AMPK2
• PRKAA
• AMPKa2

Llyfryddiaeth

• "Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy. ". Neoplasia. 2006. PMID 16984726.
• "AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. ". J Med Genet. 2006. PMID 16801347.
• "Prognostic Significance of AMP-Dependent Kinase Alpha Expression in Cervical Cancer. ". Pathobiology. 2015. PMID 26337566.
• "Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain. ". Acta Crystallogr D Biol Crystallogr. 2011. PMID 21543851.
• "Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action.". Am J Physiol Endocrinol Metab. 2009. PMID 19470831.