PRDX3

PRDX3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 5JCG
Dynodwyr
Cyfenwau	PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III, peroxiredoxin 3, SCAR32, PPPCD
Dynodwyr allanol	OMIM: 604769 HomoloGene: 4944 GeneCards: PRDX3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peroxidase activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • kinase binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • antioxidant activity • alkyl hydroperoxide reductase activity • peroxiredoxin activity • oxidoreductase activity • protein kinase binding • thioredoxin peroxidase activity • identical protein binding Cydrannau o'r gell • cytosol • myelin sheath • mitochondrial matrix • mitocondria • IkappaB kinase complex • cytoplasm • endosome • early endosome • GO:0009327 protein-containing complex Prosesau biolegol • myeloid cell differentiation • peptidyl-cysteine oxidation • mitochondrion organization • negative regulation of apoptotic process • GO:0001306 response to oxidative stress • regulation of mitochondrial membrane potential • GO:0072353 cellular response to reactive oxygen species • response to lipopolysaccharide • maternal placenta development • positive regulation of NF-kappaB transcription factor activity • positive regulation of cell population proliferation • hydrogen peroxide catabolic process • response to hydrogen peroxide • negative regulation of kinase activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular oxidant detoxification • cell redox homeostasis • GO:0097285 apoptotic process • cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10935	n/a
Ensembl	ENSG00000165672	n/a
UniProt	P30048	n/a
RefSeq (mRNA)	NM_001302272 NM_006793 NM_014098	n/a
RefSeq (protein)	NP_001289201 NP_006784	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRDX3 yw PRDX3 a elwir hefyd yn Peroxiredoxin 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q26.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRDX3.

• AOP1
• MER5
• AOP-1
• SP-22
• HBC189
• PRO1748
• prx-III

Llyfryddiaeth

• "Serum peroxiredoxin3 is a useful biomarker for early diagnosis and assessemnt of prognosis of hepatocellular carcinoma in Chinese patients. ". Asian Pac J Cancer Prev. 2014. PMID 24815434.
• "Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity. ". Int J Oncol. 2014. PMID 24789097.
• "Featured Article: Accelerated decline of physical strength in peroxiredoxin-3 knockout mice. ". Exp Biol Med (Maywood). 2016. PMID 27037278.
• "Silencing PRDX3 Inhibits Growth and Promotes Invasion and Extracellular Matrix Degradation in Hepatocellular Carcinoma Cells. ". J Proteome Res. 2016. PMID 26983019.
• "Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.". Redox Biol. 2014. PMID 25462069.