PRDX2

PRDX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QMV
Dynodwyr
Cyfenwau	PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
Dynodwyr allanol	OMIM: 600538 HomoloGene: 21182 GeneCards: PRDX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity • antioxidant activity • peroxiredoxin activity • peroxidase activity • GO:0001948, GO:0016582 protein binding • thioredoxin peroxidase activity Cydrannau o'r gell • cytoplasm • extracellular exosome • cytosol Prosesau biolegol • regulation of apoptotic process • negative regulation of apoptotic process • hydrogen peroxide catabolic process • cell redox homeostasis • GO:0001306 response to oxidative stress • cellular response to oxidative stress • removal of superoxide radicals • respiratory burst involved in inflammatory response • regulation of hydrogen peroxide metabolic process • positive regulation of blood coagulation • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • response to lipopolysaccharide • T cell proliferation • hydrogen peroxide metabolic process • negative regulation of T cell differentiation • thymus development • homeostasis of number of cells • negative regulation of reactive oxygen species metabolic process • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • leukocyte activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7001	n/a
Ensembl	ENSG00000167815	n/a
UniProt	P32119	n/a
RefSeq (mRNA)	NM_181738 NM_005809 NM_181737	n/a
RefSeq (protein)	NP_005800	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRDX2 yw PRDX2 a elwir hefyd yn Peroxiredoxin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRDX2.

• PRP
• TSA
• PRX2
• PTX1
• TPX1
• NKEFB
• PRXII
• TDPX1
• NKEF-B
• HEL-S-2a

Llyfryddiaeth

• "Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells. ". Stem Cells. 2016. PMID 26866938.
• "An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib. ". Exp Mol Med. 2015. PMID 26021759.
• "Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation. ". Int J Mol Sci. 2017. PMID 28375164.
• "Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients. ". Oncotarget. 2017. PMID 28125800.
• "Peroxiredoxin-2 up-regulation in inflammatory bowel disease: Friend or foe?". J Gastroenterol Hepatol. 2017. PMID 27869326.