PRDX1

PRDX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2RII, 3HY2, 4XCS
Dynodwyr
Cyfenwau	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2, Peroxiredoxin 1
Dynodwyr allanol	OMIM: 176763 HomoloGene: 99789 GeneCards: PRDX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • antioxidant activity • GO:0001948, GO:0016582 protein binding • peroxiredoxin activity • identical protein binding • oxidoreductase activity • thioredoxin peroxidase activity • peroxidase activity • RNA binding • cadherin binding Cydrannau o'r gell • cytoplasm • cytosol • melanosome • myelin sheath • mitocondria • extracellular exosome • cnewyllyn cell • GO:0005578 extracellular matrix • extracellular space Prosesau biolegol • skeletal system development • removal of superoxide radicals • GO:0001306 response to oxidative stress • retina homeostasis • erythrocyte homeostasis • hydrogen peroxide catabolic process • cell population proliferation • regulation of stress-activated MAPK cascade • natural killer cell mediated cytotoxicity • cell redox homeostasis • natural killer cell activation • GO:0001315 response to reactive oxygen species • cellular response to oxidative stress • regulation of NIK/NF-kappaB signaling • leukocyte activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5052	n/a
Ensembl	ENSG00000117450	n/a
UniProt	Q06830	n/a
RefSeq (mRNA)	NM_181697 NM_001202431 NM_002574 NM_181696	n/a
RefSeq (protein)	NP_001189360 NP_002565 NP_859047 NP_859048	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRDX1 yw PRDX1 a elwir hefyd yn Peroxiredoxin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p34.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRDX1.

• PAG
• PAGA
• PAGB
• PRX1
• PRXI
• MSP23
• NKEFA
• TDPX2
• NKEF-A

Llyfryddiaeth

• "Peroxiredoxin 1 (Prx1) is a dual-function enzyme by possessing Cys-independent catalase-like activity. ". Biochem J. 2017. PMID 28219939.
• "Dual role of the active-center cysteine in human peroxiredoxin 1: Peroxidase activity and heme binding. ". Biochem Biophys Res Commun. 2017. PMID 28082197.
• "Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase. ". Cell Rep. 2016. PMID 28009281.
• "S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection. ". Biochim Biophys Acta. 2017. PMID 27612662.
• "Peroxiredoxin 1 promotes invasion and migration by regulating epithelial-to-mesenchymal transition during oral carcinogenesis.". Oncotarget. 2016. PMID 27259998.