PPP3CA

PPP3CA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V
Dynodwyr
Cyfenwau	PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91
Dynodwyr allanol	OMIM: 114105 HomoloGene: 55497 GeneCards: PPP3CA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • phosphoprotein phosphatase activity • protein dimerization activity • protein serine/threonine phosphatase activity • metal ion binding • calmodulin binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • enzyme binding • calcium-dependent protein serine/threonine phosphatase activity • hydrolase activity • cyclosporin A binding • calmodulin-dependent protein phosphatase activity Cydrannau o'r gell • bilen • Cellbilen • calcineurin complex • nucleoplasm • Z disc • mitocondria • sarcolemma • cnewyllyn cell • cytosol • cytoplasm • cytoplasmic side of plasma membrane • dendritic spine • slit diaphragm • cell projection • synapse • Schaffer collateral - CA1 synapse • glutamatergic synapse Prosesau biolegol • multicellular organismal response to stress • negative regulation of insulin secretion • protein import into nucleus • transition between fast and slow fiber • negative regulation of chromatin binding • response to amphetamine • modulation of chemical synaptic transmission • positive regulation of DNA-binding transcription factor activity • response to calcium ion • Fc-epsilon receptor signaling pathway • cardiac muscle hypertrophy in response to stress • negative regulation of dendrite morphogenesis • skeletal muscle fiber development • positive regulation of cardiac muscle hypertrophy in response to stress • excitatory postsynaptic potential • T cell activation • cellular response to glucose stimulus • calcium ion transport • calcium-mediated signaling • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Wnt signaling pathway, calcium modulating pathway • positive regulation of cardiac muscle hypertrophy • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • negative regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of connective tissue replacement • positive regulation of endocytosis • G1/S transition of mitotic cell cycle • GO:0016576 protein dephosphorylation • calcineurin-NFAT signaling cascade • positive regulation of calcineurin-NFAT signaling cascade • brain development • positive regulation of cell migration • skeletal muscle tissue regeneration • positive regulation of cell adhesion • calcineurin-mediated signaling • postsynaptic modulation of chemical synaptic transmission • GO:0010260 heneiddio • peptidyl-serine dephosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5530	n/a
Ensembl	ENSG00000138814	n/a
UniProt	Q08209	n/a
RefSeq (mRNA)	NM_001130692 NM_000944 NM_001130691	n/a
RefSeq (protein)	NP_000935 NP_001124163 NP_001124164	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP3CA yw PPP3CA a elwir hefyd yn Protein phosphatase 3 catalytic subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q24.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP3CA.

• CALN
• CCN1
• CNA1
• CALNA
• IECEE
• PPP2B
• CALNA1

Llyfryddiaeth

• "Increased ratio of calcineurin immunoreactive neurons in the caudate nucleus of patients with schizophrenia. ". Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID 22285318.
• "The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis. ". Clin Exp Metastasis. 2011. PMID 21785830.
• "De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. ". Am J Hum Genet. 2017. PMID 28942967.
• "The distal helix in the regulatory domain of calcineurin is important for domain stability and enzyme function. ". Biochemistry. 2013. PMID 24191726.
• "Crystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID 22691791.