PPP2R5C

PPP2R5C
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IAE, 2JAK, 2NPP, 2NYL, 2NYM, 3FGA, 5JJA
Dynodwyr
Cyfenwau	PPP2R5C, B56G, PR61G, protein phosphatase 2 regulatory subunit B'gamma, B56gamma
Dynodwyr allanol	OMIM: 601645 HomoloGene: 135298 GeneCards: PPP2R5C
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein phosphatase regulator activity • protein phosphatase activator activity Cydrannau o'r gell • protein phosphatase type 2A complex • chromosome, centromeric region • cnewyllyn cell • Cromosom • nucleoplasm • Golgi apparatus • cytosol Prosesau biolegol • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:0072468 signal transduction • negative regulation of cell population proliferation • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of phosphatidylinositol 3-kinase signaling • regulation of phosphoprotein phosphatase activity • regulation of protein autophosphorylation • GO:0016576 protein dephosphorylation • negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5527	n/a
Ensembl	ENSG00000078304	n/a
UniProt	Q13362	n/a
RefSeq (mRNA)	NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587 NM_178588 NM_001352912 NM_001352913 NM_001352914 NM_001352915 NM_001352916	n/a
RefSeq (protein)	NP_001155197 NP_001155198 NP_002710 NP_848701 NP_848702 NP_001339841 NP_001339842 NP_001339843 NP_001339844 NP_001339845	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP2R5C yw PPP2R5C a elwir hefyd yn Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform a Protein phosphatase 2 regulatory subunit B'gamma (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP2R5C.

• B56G
• PR61G
• B56gamma

Llyfryddiaeth

• "Differential gene expression profiles of PPP2R5C-siRNA-treated malignant T cells. ". DNA Cell Biol. 2013. PMID 23941244.
• "B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity. ". Mol Cancer Res. 2013. PMID 23723076.
• "Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene. ". Oncol Rep. 2016. PMID 26986830.
• "PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis. ". PLoS Genet. 2015. PMID 26440364.
• "Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells.". J Hematol Oncol. 2015. PMID 25888193.