PPP2R1A

PPP2R1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W
Dynodwyr
Cyfenwau	PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
Dynodwyr allanol	OMIM: 605983 HomoloGene: 68559 GeneCards: PPP2R1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein serine/threonine phosphatase activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • protein phosphatase regulator activity • protein antigen binding Cydrannau o'r gell • cytoplasm • cytosol • microtubule cytoskeleton • protein phosphatase type 2A complex • Cromosom • mitocondria • chromosome, centromeric region • extracellular exosome • cnewyllyn cell • Cellbilen • bilen • lateral plasma membrane • dendrite • cell projection • synapse • glutamatergic synapse Prosesau biolegol • GO:0097285 apoptotic process • regulation of meiotic cell cycle process involved in oocyte maturation • meiotic sister chromatid cohesion, centromeric • GO:0009373 regulation of transcription, DNA-templated • ceramide metabolic process • regulation of DNA replication • chromosome segregation • GO:0016576 protein dephosphorylation • meiotic spindle elongation • female meiotic nuclear division • response to organic substance • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • peptidyl-serine dephosphorylation • regulation of Wnt signaling pathway • regulation of cell adhesion • G2/M transition of mitotic cell cycle • negative regulation of cell growth • RNA splicing • regulation of cell differentiation • regulation of growth • mitotic nuclear membrane reassembly • mitotic sister chromatid separation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • second-messenger-mediated signaling • ciliary basal body-plasma membrane docking • negative regulation of tyrosine phosphorylation of STAT protein • regulation of G2/M transition of mitotic cell cycle • regulation of phosphoprotein phosphatase activity • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5518	n/a
Ensembl	ENSG00000105568	n/a
UniProt	P30153	n/a
RefSeq (mRNA)	NM_014225 NM_001363656	n/a
RefSeq (protein)	NP_055040 NP_001350585 NP_055040.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP2R1A yw PPP2R1A a elwir hefyd yn Protein phosphatase 2 scaffold subunit Aalpha a Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.41.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP2R1A.

• MRD36
• PP2AA
• PR65A
• PP2AAALPHA
• PP2A-Aalpha

Llyfryddiaeth

• "Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma. ". PLoS One. 2013. PMID 23555712.
• "PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes. ". Anticancer Res. 2013. PMID 23267135.
• "Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth. ". Cancer Res. 2016. PMID 27485451.
• "Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiation. ". J Biomed Sci. 2014. PMID 24885237.
• "Complex energy landscape of a giant repeat protein.". Structure. 2013. PMID 24120762.