PPP2CA

PPP2CA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IAE, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 3C5W, 3DW8, 3FGA, 3K7V, 3K7W, 3P71, 4I5L, 4I5N, 4IYP, 4LAC
Dynodwyr
Cyfenwau	PPP2CA, PP2Ac, PP2CA, PP2Calpha, RP-C, protein phosphatase 2 catalytic subunit alpha, NEDLBA
Dynodwyr allanol	OMIM: 176915 HomoloGene: 37660 GeneCards: PPP2CA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • GABA receptor binding • metal ion binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • protein heterodimerization activity • protein serine/threonine phosphatase activity • tau protein binding Cydrannau o'r gell • cytoplasm • cytosol • spindle pole • bilen • microtubule cytoskeleton • Cellbilen • protein phosphatase type 2A complex • Cromosom • mitocondria • chromosome, centromeric region • Cytosgerbwd • extracellular exosome • cnewyllyn cell • membrane raft • synapse Prosesau biolegol • GO:0097285 apoptotic process • GO:0009373 regulation of transcription, DNA-templated • ceramide metabolic process • regulation of DNA replication • GO:0016576 protein dephosphorylation • response to organic substance • positive regulation of protein serine/threonine kinase activity • regulation of Wnt signaling pathway • regulation of cell adhesion • GO:0007126 Meiosis • negative regulation of cell growth • RNA splicing • regulation of cell differentiation • regulation of growth • mitotic nuclear membrane reassembly • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mesoderm development • second-messenger-mediated signaling • negative regulation of epithelial to mesenchymal transition • negative regulation of tyrosine phosphorylation of STAT protein • regulation of protein phosphorylation • response to lead ion • peptidyl-threonine dephosphorylation • peptidyl-serine dephosphorylation • regulation of microtubule binding • positive regulation of microtubule binding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5515	n/a
Ensembl	ENSG00000113575	n/a
UniProt	P67775	n/a
RefSeq (mRNA)	NM_002715 NM_001355019	n/a
RefSeq (protein)	NP_002706 NP_001341948	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP2CA yw PPP2CA a elwir hefyd yn Protein phosphatase 2 catalytic subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP2CA.

• RP-C
• PP2Ac
• PP2CA
• PP2Calpha

Llyfryddiaeth

• "Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer. ". Br J Cancer. 2014. PMID 25003662.
• "Protein phosphatase 2A (PP2A) regulates low density lipoprotein uptake through regulating sterol response element-binding protein-2 (SREBP-2) DNA binding. ". J Biol Chem. 2014. PMID 24770487.
• "Characterization of overexpression of the alternatively spliced isoform of the protein phosphatase 2A catalytic subunit in cells. ". Biochem Biophys Res Commun. 2017. PMID 29066346.
• "Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma. ". Mol Cancer Ther. 2015. PMID 25939762.
• "The catalytic role of the M2 metal ion in PP2Cα.". Sci Rep. 2015. PMID 25708299.