PPP1R8

PPP1R8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3V4Y
Dynodwyr
Cyfenwau	PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8
Dynodwyr allanol	OMIM: 602636 HomoloGene: 8555 GeneCards: PPP1R8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein serine/threonine phosphatase inhibitor activity • DNA binding • GO:0001948, GO:0016582 protein binding • RNA binding • protein phosphatase inhibitor activity • nuclease activity • endonuclease activity • ribonuclease E activity • hydrolase activity • mRNA binding • protein phosphatase regulator activity Cydrannau o'r gell • cytoplasm • nuclear speck • nucleoplasm • spliceosomal complex • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • nucleic acid phosphodiester bond hydrolysis • mRNA processing • RNA catabolic process • transcription, DNA-templated • RNA splicing • cell population proliferation • RNA phosphodiester bond hydrolysis • negative regulation of protein dephosphorylation • negative regulation of phosphoprotein phosphatase activity • regulation of phosphoprotein phosphatase activity • production of miRNAs involved in gene silencing by miRNA Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5511	n/a
Ensembl	ENSG00000117751	n/a
UniProt	Q12972	n/a
RefSeq (mRNA)	NM_138558 NM_002713 NM_014110	n/a
RefSeq (protein)	NP_002704 NP_054829 NP_612568	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP1R8 yw PPP1R8 a elwir hefyd yn Nuclear inhibitor of protein phosphatase 1 a Protein phosphatase 1 regulatory subunit 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p35.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP1R8.

• ARD1
• ARD-1
• NIPP1
• NIPP-1
• PRO2047

Llyfryddiaeth

• "Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. ". J Cell Sci. 2000. PMID 11034904.
• "Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. ". Gene. 1999. PMID 10564811.
• "Protein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells. ". FEBS Lett. 2015. PMID 25907536.
• "The NMR structure of the NIPP1 FHA domain. ". J Biomol NMR. 2008. PMID 18253837.
• "The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly.". J Biol Chem. 2002. PMID 11909864.