PPP1R12A

PPP1R12A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KJY, 2MXR, 5HUZ
Dynodwyr
Cyfenwau	PPP1R12A, M130, MBS, MYPT1, protein phosphatase 1 regulatory subunit 12A, GUBS
Dynodwyr allanol	OMIM: 602021 HomoloGene: 1855 GeneCards: PPP1R12A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0048551 enzyme inhibitor activity • 14-3-3 protein binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • protein kinase binding • phosphatase regulator activity Cydrannau o'r gell • centrosome • focal adhesion • nucleoplasm • Z disc • PTW/PP1 phosphatase complex • actin cytoskeleton • contractile fiber • A band • kinetochore • cytoplasm • cytosol • Cytosgerbwd Prosesau biolegol • regulation of nucleocytoplasmic transport • positive regulation of myosin-light-chain-phosphatase activity • GO:0048553 negative regulation of catalytic activity • regulation of cell adhesion • G2/M transition of mitotic cell cycle • regulation of myosin-light-chain-phosphatase activity • regulation of establishment of endothelial barrier • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • GO:0016576 protein dephosphorylation • GO:0007067 Mitosis • centrosome cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4659	n/a
Ensembl	ENSG00000058272	n/a
UniProt	O14974	n/a
RefSeq (mRNA)	NM_001143885 NM_001143886 NM_001244990 NM_001244992 NM_002480	n/a
RefSeq (protein)	NP_001137357 NP_001137358 NP_001231919 NP_001231921 NP_002471	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP1R12A yw PPP1R12A a elwir hefyd yn Protein phosphatase 1 regulatory subunit 12A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q21.2-q21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP1R12A.

• MBS
• M130
• MYPT1

Llyfryddiaeth

• "MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer. ". Mol Cancer. 2017. PMID 28241827.
• "Differential phosphorylation of LZ+/LZ- MYPT1 isoforms regulates MLC phosphatase activity. ". Arch Biochem Biophys. 2014. PMID 25168281.
• "Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1. ". Biochemistry. 2014. PMID 24712327.
• "MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint. ". J Genet Genomics. 2013. PMID 24238611.
• "cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway.". Blood. 2013. PMID 24100445.