PPP1CA

PPP1CA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3E7A, 3E7B, 3EGG, 3EGH, 3HVQ, 3N5U, 3V4Y, 4G9J, 4MOV, 4MOY, 4MP0, 4XPN, 1FJM
Dynodwyr
Cyfenwau	PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A, protein phosphatase 1 catalytic subunit alpha
Dynodwyr allanol	OMIM: 176875 HomoloGene: 105262 GeneCards: PPP1CA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • cadherin binding involved in cell-cell adhesion • protein serine/threonine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • protein phosphatase 1 binding • ribonucleoprotein complex binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • Cellbilen • nucleoplasm • PTW/PP1 phosphatase complex • nucleolus • extracellular exosome • cnewyllyn cell • cytosol • protein phosphatase type 1 complex • glycogen granule • neuron projection • neuronal cell body • dendritic spine • perikaryon • presynapse • postsynapse • glutamatergic synapse Prosesau biolegol • regulation of canonical Wnt signaling pathway • negative regulation of protein binding • Cellraniad • glycogen metabolic process • cell cycle • regulation of translational initiation by eIF2 alpha dephosphorylation • beta-catenin destruction complex disassembly • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • cell-cell adhesion • GO:0016576 protein dephosphorylation • circadian regulation of gene expression • regulation of circadian rhythm • entrainment of circadian clock by photoperiod • carbohydrate metabolic process • regulation of glycogen biosynthetic process • regulation of glycogen catabolic process • response to lead ion • lung development • peptidyl-threonine dephosphorylation • branching morphogenesis of an epithelial tube • peptidyl-serine dephosphorylation • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5499	n/a
Ensembl	ENSG00000172531	n/a
UniProt	P62136	n/a
RefSeq (mRNA)	NM_206873 NM_001008709 NM_002708	n/a
RefSeq (protein)	NP_001008709 NP_002699 NP_996756	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP1CA yw PPP1CA a elwir hefyd yn Serine/threonine-protein phosphatase PP1-alpha catalytic subunit a Protein phosphatase 1 catalytic subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP1CA.

• PP1A
• PP-1A
• PPP1A
• PP1alpha

Llyfryddiaeth

• "The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis. ". Exp Cell Res. 2015. PMID 25556058.
• "Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes. ". Cancer Res. 2010. PMID 20663907.
• "Analysis of Autoantibodies Related to Tumor Progression in Sera from Patients with High-grade Non-muscle-invasive Bladder Cancer. ". Anticancer Res. 2017. PMID 29187447.
• "Biogenesis and activity regulation of protein phosphatase 1. ". Biochem Soc Trans. 2017. PMID 28202662.
• "Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells.". Apoptosis. 2015. PMID 26033480.