PPIF

PPIF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BIT, 2BIU, 2Z6W, 3QYU, 3R49, 3R4G, 3R54, 3R56, 3R57, 3R59, 3RCF, 3RCG, 3RCI, 3RCK, 3RCL, 3RD9, 3RDA, 3RDB, 3RDC, 4J58, 4J59, 4J5A, 4J5B, 4J5C, 4J5D, 4J5E, 4O8H, 4O8I, 4XNC, 4ZSC, 4ZSD, 5A0E, 5CCS, 5CCN, 5CCQ, 5CBT, 5CCR
Dynodwyr
Cyfenwau	PPIF, CYP3, CyP-M, Cyp-D, CypD, peptidylprolyl isomerase F
Dynodwyr allanol	OMIM: 604486 HomoloGene: 38696 GeneCards: PPIF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptide binding • isomerase activity • GO:0001948, GO:0016582 protein binding • peptidyl-prolyl cis-trans isomerase activity • cyclosporin A binding • unfolded protein binding Cydrannau o'r gell • mitochondrial proton-transporting ATP synthase complex • bilen • mitochondrial inner membrane • mitocondria • mitochondrial matrix • mitochondrial permeability transition pore complex Prosesau biolegol • regulation of apoptotic process • cellular response to calcium ion • GO:0010703, GO:0010702 programmed cell death • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of ATP-dependent activity • negative regulation of release of cytochrome c from mitochondria • negative regulation of apoptotic process • GO:0001306 response to oxidative stress • regulation of necrotic cell death • regulation of mitochondrial membrane permeability involved in programmed necrotic cell death • response to ischemia • protein folding • cellular response to arsenic-containing substance • negative regulation of oxidative phosphorylation uncoupler activity • regulation of proton-transporting ATPase activity, rotational mechanism • positive regulation of release of cytochrome c from mitochondria • GO:0060554, GO:0060555 necroptosis • negative regulation of oxidative phosphorylation • cellular response to hydrogen peroxide • GO:0097285 apoptotic process • apoptotic mitochondrial changes • regulation of mitochondrial membrane permeability • mitochondrial outer membrane permeabilization involved in programmed cell death • protein peptidyl-prolyl isomerization • protein refolding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10105	n/a
Ensembl	ENSG00000108179	n/a
UniProt	P30405	n/a
RefSeq (mRNA)	NM_005729	n/a
RefSeq (protein)	NP_005720	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPIF yw PPIF a elwir hefyd yn Peptidylprolyl isomerase F (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPIF.

• CYP3
• CypD
• CyP-M
• Cyp-D

Llyfryddiaeth

• "Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes. ". Genomics. 2000. PMID 10903836.
• "Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. ". Biochem J. 2002. PMID 12149099.
• "Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. ". Invest Ophthalmol Vis Sci. 2008. PMID 18614807.
• "Genomic characterization of the human peptidyl-prolyl-cis-trans-isomerase, mitochondrial precursor gene: assessment of its role in familial dilated cardiomyopathy. ". Hum Genet. 1999. PMID 10647893.
• "The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.". J Biol Chem. 1991. PMID 1744118.