PPIB

PPIB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CYN, 3ICH, 3ICI
Dynodwyr
Cyfenwau	PPIB, CYP-S1, CYPB, HEL-S-39, OI9, SCYLP, peptidylprolyl isomerase B, B
Dynodwyr allanol	OMIM: 123841 HomoloGene: 726 GeneCards: PPIB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • collagen binding • unfolded protein binding • GO:0032403 protein-containing complex binding • isomerase activity • GO:0001948, GO:0016582 protein binding • RNA polymerase binding • RNA binding • peptidyl-prolyl cis-trans isomerase activity • cyclosporin A binding Cydrannau o'r gell • GO:0009327 protein-containing complex • endoplasmic reticulum lumen • bilen • focal adhesion • melanosome • smooth endoplasmic reticulum • endoplasmic reticulum chaperone complex • Reticwlwm endoplasmig • perinuclear region of cytoplasm • extracellular exosome • cnewyllyn cell Prosesau biolegol • protein stabilization • regulation of post-translational protein modification • protein peptidyl-prolyl isomerization • positive regulation by host of viral genome replication • positive regulation by host of viral process • protein folding • positive regulation of multicellular organism growth • bone development • chaperone-mediated protein folding • protein refolding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5479	n/a
Ensembl	ENSG00000166794	n/a
UniProt	P23284	n/a
RefSeq (mRNA)	NM_000942	n/a
RefSeq (protein)	NP_000933	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPIB yw PPIB a elwir hefyd yn Peptidylprolyl isomerase B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q22.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPIB.

• OI9
• CYPB
• SCYLP
• CYP-S1
• HEL-S-39

Llyfryddiaeth

• "Expression and role of cyclophilin B in stomach cancer. ". Genet Mol Res. 2015. PMID 26125731.
• "Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. ". J Clin Invest. 2012. PMID 22484812.
• "Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX. ". Clin Chim Acta. 2017. PMID 28242392.
• "Cyclophilin B protects SH-SY5Y human neuroblastoma cells against MPP(+)-induced neurotoxicity via JNK pathway. ". Biochem Biophys Res Commun. 2016. PMID 27569281.
• "Cyclophilin B enhances HIV-1 infection.". Virology. 2016. PMID 26774171.