POU1F1

POU1F1
Dynodwyr
Cyfenwau	POU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
Dynodwyr allanol	OMIM: 173110 HomoloGene: 259 GeneCards: POU1F1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • GO:0001106 transcription corepressor activity • GO:0001105 transcription coactivator activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • transcription regulator complex • chromatin Prosesau biolegol • negative regulation of cell population proliferation • somatotropin secreting cell development • adenohypophysis development • positive regulation of inositol trisphosphate biosynthetic process • regulation of insulin-like growth factor receptor signaling pathway • pituitary gland development • GO:0009373 regulation of transcription, DNA-templated • cell fate specification • B cell differentiation • positive regulation of cell population proliferation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • determination of adult lifespan • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of multicellular organism growth • nuclear transport • GO:1901227 negative regulation of transcription by RNA polymerase II • somatotropin secreting cell differentiation • transcription, DNA-templated • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5449	n/a
Ensembl	ENSG00000064835	n/a
UniProt	P28069	n/a
RefSeq (mRNA)	NM_001122757 NM_000306	n/a
RefSeq (protein)	NP_000297 NP_001116229	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POU1F1 yw POU1F1 a elwir hefyd yn POU class 1 homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POU1F1.

• PIT1
• CPHD1
• GHF-1
• Pit-1
• POU1F1a

Llyfryddiaeth

• "A novel heterozygous intronic mutation in POU1F1 is associated with combined pituitary hormone deficiency. ". Endocr J. 2017. PMID 27885216.
• "Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients. ". Med Sci Monit. 2016. PMID 27798557.
• "Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas. ". Mod Pathol. 2016. PMID 26743473.
• "Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome. ". J Clin Endocrinol Metab. 2014. PMID 24937538.
• "Research resource: A genome-wide study identifies potential new target genes for POU1F1.". Mol Endocrinol. 2012. PMID 22638072.