POR

POR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B1C, 3FJO, 3QE2, 3QFC, 3QFR, 3QFS, 3QFT
Dynodwyr
Cyfenwau	POR, CPR, CYP450R, cytochrome p450 oxidoreductase, P450 oxidoreductase
Dynodwyr allanol	OMIM: 124015 HomoloGene: 725 GeneCards: POR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • FMN binding • NADPH-hemoprotein reductase activity • flavin adenine dinucleotide binding • cytochrome-b5 reductase activity, acting on NAD(P)H • GO:0001948, GO:0016582 protein binding • NADP binding • electron transfer activity • enzyme binding • oxidoreductase activity • iron-cytochrome-c reductase activity • hydrolase activity • nitric oxide dioxygenase activity Cydrannau o'r gell • integral component of membrane • bilen • intracellular membrane-bounded organelle • mitocondria • Reticwlwm endoplasmig • endoplasmic reticulum membrane • cytoplasm • cytosol Prosesau biolegol • regulation of growth plate cartilage chondrocyte proliferation • nitrate catabolic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to follicle-stimulating hormone stimulus • positive regulation of smoothened signaling pathway • response to nutrient • demethylation • nitric oxide catabolic process • negative regulation of apoptotic process • positive regulation of monooxygenase activity • negative regulation of lipase activity • internal peptidyl-lysine acetylation • regulation of cholesterol metabolic process • cellular response to peptide hormone stimulus • fatty acid oxidation • positive regulation of chondrocyte differentiation • cellular organofluorine metabolic process • flavonoid metabolic process • positive regulation of cholesterol biosynthetic process • positive regulation of steroid hormone biosynthetic process • cellular response to gonadotropin stimulus • carnitine metabolic process • xenobiotic metabolic process • electron transport chain • response to hormone Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5447	n/a
Ensembl	ENSG00000127948	n/a
UniProt	P16435	n/a
RefSeq (mRNA)	NM_000941 NM_001367562	n/a
RefSeq (protein)	NP_000932 NP_001354491 NP_001369584 NP_001369586 NP_001369587 NP_001369588 NP_001369591	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POR yw POR a elwir hefyd yn NADPH--cytochrome P450 reductase a Cytochrome p450 oxidoreductase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q11.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POR.

• CPR
• CYPOR
• P450R

Llyfryddiaeth

• "Associations of cytochrome P450 oxidoreductase genetic polymorphisms with smoking cessation in a Chinese population. ". Hum Genet. 2016. PMID 27660057.
• "Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. ". J Biol Chem. 2016. PMID 27496950.
• "Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese. ". Eur J Clin Pharmacol. 2016. PMID 27488389.
• "Role of active site loop in coenzyme binding and flavin reduction in cytochrome P450 reductase. ". Arch Biochem Biophys. 2016. PMID 27461959.
• "Delayed diagnosis of disorder of sex development (DSD) due to P450 oxidoreductase (POR) deficiency.". Hormones (Athens). 2016. PMID 27376429.