PON1

PON1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1V04
Dynodwyr
Cyfenwau	PON1, ESA, MVCD5, PON, paraoxonase 1
Dynodwyr allanol	OMIM: 168820 HomoloGene: 68058 GeneCards: PON1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • protein homodimerization activity • metal ion binding • aryldialkylphosphatase activity • arylesterase activity • hydrolase activity • phospholipid binding • acyl-L-homoserine-lactone lactonohydrolase activity Cydrannau o'r gell • blood microparticle • intracellular membrane-bounded organelle • spherical high-density lipoprotein particle • high-density lipoprotein particle • extracellular exosome • extracellular region • extracellular space Prosesau biolegol • response to fatty acid • positive regulation of transporter activity • negative regulation of plasma lipoprotein oxidation • lipid metabolism • carboxylic acid catabolic process • cholesterol metabolic process • positive regulation of binding • response to nutrient levels • response to fluoride • positive regulation of cholesterol efflux • response to external stimulus • organophosphate catabolic process • aromatic compound catabolic process • phosphatidylcholine metabolic process • response to toxic substance • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • lipoxygenase pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5444	n/a
Ensembl	ENSG00000005421	n/a
UniProt	P27169	n/a
RefSeq (mRNA)	NM_000446	n/a
RefSeq (protein)	NP_000437	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PON1 yw PON1 a elwir hefyd yn Paraoxonase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PON1.

• ESA
• PON
• MVCD5

Llyfryddiaeth

• "The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study. ". Medicine (Baltimore). 2017. PMID 29049204.
• "Correlation of PON1 polymorphisms with ankylosing spondylitis susceptibility: A case-control study in Chinese Han population. ". Medicine (Baltimore). 2017. PMID 29049176.
• "The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry. ". BMC Med Genet. 2017. PMID 29233102.
• "[The role of lipoprotein-associated enzyme paraoxonase 1 and its polymorphisms in the pathogenesis of endothelial dysfunction and somatic complications in patients with alcoholism: Review ]. ". Patol Fiziol Eksp Ter. 2016. PMID 29215249.
• "Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients.". PLoS One. 2017. PMID 29176871.