POLR2A

POLR2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GHQ, 2GHT, 2LTO, 3D9K, 3D9L, 3D9M, 3D9N, 3D9O, 3D9P, 4JXT, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Dynodwyr
Cyfenwau	POLR2A, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, polymerase (RNA) II subunit A, RNA polymerase II subunit A, NEDHIB
Dynodwyr allanol	OMIM: 180660 HomoloGene: 721 GeneCards: POLR2A
EC number	2.7.7.48
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • nucleotidyltransferase activity • RNA polymerase II activity • metal ion binding • RNA-directed 5'-3' RNA polymerase activity • DNA-directed 5'-3' RNA polymerase activity • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • RNA binding • protein C-terminus binding • promoter-specific chromatin binding Cydrannau o'r gell • Prp19 complex • nucleolus • RNA polymerase II, core complex • cnewyllyn cell • nucleoplasm • cytoplasm Prosesau biolegol • mRNA splicing, via spliceosome • GO:0009373 regulation of transcription, DNA-templated • somatic stem cell population maintenance • DNA-templated transcription, termination • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription by RNA polymerase II • transcription, RNA-templated • positive regulation of RNA splicing • positive regulation of viral transcription • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • snRNA transcription by RNA polymerase II • fibroblast growth factor receptor signaling pathway • transcription, DNA-templated • RNA metabolic process • GO:1905616 regulation of gene silencing by miRNA Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5430	n/a
Ensembl	ENSG00000284832 ENSG00000181222	n/a
UniProt	P24928	n/a
RefSeq (mRNA)	NM_000937	n/a
RefSeq (protein)	NP_000928	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ' yw POLR2A a elwir hefyd yn RNA polymerase II subunit A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLR2A.

• RPB1
• RPO2
• POLR2
• POLRA
• RPBh1
• RPOL2
• RpIILS
• hsRPB1
• hRPB220

Llyfryddiaeth

• "Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome. ". Nucleic Acids Res. 2017. PMID 28977633.
• "Kaposi's Sarcoma-Associated Herpesvirus Hijacks RNA Polymerase II To Create a Viral Transcriptional Factory. ". J Virol. 2017. PMID 28331082.
• "Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. ". Nat Genet. 2016. PMID 27548314.
• "Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain. ". BMC Res Notes. 2015. PMID 26515650.
• "The CD8+ cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+ cells.". J Gen Virol. 2016. PMID 26499373.