POLL

POLL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NZP, 1RZT, 1XSL, 1XSN, 1XSP, 2BCQ, 2BCR, 2BCS, 2BCU, 2BCV, 2GWS, 2JW5, 2PFN, 2PFO, 2PFP, 2PFQ, 3C5F, 3C5G, 3HW8, 3HWT, 3HX0, 3MDA, 3MDC, 3MGH, 3MGI, 3PML, 3PMN, 3PNC, 3UPQ, 3UQ0, 3UQ2, 4FO6, 4K4G, 4K4H, 4K4I, 4XA5, 4XUS, 4X5V, 5CR0, 4XQ8, 5CJ7, 5DKW, 5CP2, 5DDY, 5DDM, 5CB1, 5CWR, 4XRH, 5CHG, 5CA7
Dynodwyr
Cyfenwau	POLL, BETAN, POLKAPPA, polymerase (DNA) lambda, DNA polymerase lambda
Dynodwyr allanol	OMIM: 606343 HomoloGene: 40863 GeneCards: POLL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • nucleotidyltransferase activity • GO:0001948, GO:0016582 protein binding • metal ion binding • lyase activity • DNA-directed DNA polymerase activity • 5'-deoxyribose-5-phosphate lyase activity • DNA polymerase • DNA polymerase activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm Prosesau biolegol • DNA replication • nucleotide-excision repair • somatic hypermutation of immunoglobulin genes • cellular response to DNA damage stimulus • GO:0100026 DNA repair • double-strand break repair via homologous recombination • base-excision repair, gap-filling • double-strand break repair via nonhomologous end joining • DNA biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	27343	n/a
Ensembl	ENSG00000166169	n/a
UniProt	Q9UGP5	n/a
RefSeq (mRNA)	NM_001174084 NM_001174085 NM_001308382 NM_013274	n/a
RefSeq (protein)	NP_001167555 NP_001167556 NP_001295311 NP_037406	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLL yw POLL a elwir hefyd yn DNA polymerase lambda (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q24.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLL.

• BETAN
• POLKAPPA

Llyfryddiaeth

• "Unlike catalyzing error-free bypass of 8-oxodGuo, DNA polymerase λ is responsible for a significant part of Fapy·dG-induced G → T mutations in human cells. ". Biochemistry. 2015. PMID 25741586.
• "Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase λ. ". Proc Natl Acad Sci U S A. 2014. PMID 25015085.
• "Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis. ". Chem Res Toxicol. 2017. PMID 28841305.
• "Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein. ". Mol Cancer Res. 2016. PMID 27621267.
• "A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG.". EMBO J. 2016. PMID 27481934.