POLH

POLH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I5O, 4RNM, 4J9O, 4YQW, 4YR0, 4ECX, 4ECS, 4ECT, 2LSK, 4DL5, 4ECR, 4DL3, 4J9K, 3MR5, 4J9N, 3SI8, 4YP3, 4O3N, 5EWE, 4ECU, 4DL6, 3MR6, 4RNN, 3MR3, 4ECY, 4O3P, 4RNO, 4ECQ, 4O3O, 4O3S, 4ECV, 4J9P, 4Q8F, 4ED3, 4ECZ, 4DL2, 4ECW, 3WUP, 5EWF, 4ED7, 4YR2, 4EEY, 4ED8, 4J9S, 3JAA, 4J9M, 4J9Q, 3MR2, 3TQ1, 4ED6, 4DL7, 4J9R, 4ED0, 4YR3, 4O3Q, 4ED1, 4J9L, 4DL4, 4O3R, 4RU9, 5EWG, 4ED2, 4Q8E, 5KG6, 5DGB, 5KFT, 5DG8, 5KFV, 5KFH, 5KG7, 5KG0, 5KFN, 5KFZ, 5KG1, 5KFX, 5KFC, 5KFU, 5KFA, 5KFK, 5KFI, 5KG4, 5KFQ, 5KFO, 5KFE, 5KFD, 5KFG, 5KG2, 5KFR, 5KFP, 5KG3, 5KFM, 5KFW, 5DGA, 5KFB, 5DG7, 5KFF, 5KFJ, 5DG9, 5L9X, 5KG5, 5KFS, 5KFL, 5KFY
Dynodwyr
Cyfenwau	POLH, RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta
Dynodwyr allanol	OMIM: 603968 HomoloGene: 38189 GeneCards: POLH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • nucleotidyltransferase activity • metal ion binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • DNA-directed DNA polymerase activity Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytosol • replication fork • site of double-strand break Prosesau biolegol • DNA synthesis involved in DNA repair • pyrimidine dimer repair • DNA biosynthetic process • postreplication repair • error-free translesion synthesis • regulation of DNA repair • cellular response to DNA damage stimulus • DNA replication • cellular response to UV-C • translesion synthesis • response to UV-C • GO:0100026 DNA repair • response to radiation • error-prone translesion synthesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5429	n/a
Ensembl	ENSG00000170734	n/a
UniProt	Q9Y253	n/a
RefSeq (mRNA)	NM_001291969 NM_001291970 NM_006502	n/a
RefSeq (protein)	NP_001278898 NP_001278899 NP_006493	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLH yw POLH a elwir hefyd yn DNA polymerase eta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLH.

• XPV
• XP-V
• RAD30
• RAD30A

Llyfryddiaeth

• "Simulating the fidelity and the three Mg mechanism of pol η and clarifying the validity of transition state theory in enzyme catalysis. ". Proteins. 2017. PMID 28383109.
• "Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity. ". Nucleic Acids Res. 2017. PMID 27994034.
• "Human DNA polymerase η accommodates RNA for strand extension. ". J Biol Chem. 2017. PMID 28972162.
• "Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle. ". Nucleic Acids Res. 2017. PMID 28934491.
• "Diagnosis of Xeroderma pigmentosum variant in a young patient with two novel mutations in the POLH gene.". Am J Med Genet A. 2017. PMID 28688171.