POLB

POLB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BPX, 1BPY, 1BPZ, 1MQ2, 1MQ3, 1TV9, 1TVA, 1ZJM, 1ZJN, 1ZQA, 1ZQB, 1ZQC, 1ZQD, 1ZQE, 1ZQF, 1ZQG, 1ZQH, 1ZQI, 1ZQJ, 1ZQK, 1ZQL, 1ZQM, 1ZQN, 1ZQO, 1ZQP, 1ZQQ, 1ZQR, 1ZQS, 1ZQT, 2FMP, 2FMQ, 2FMS, 2I9G, 2ISO, 2ISP, 2P66, 2PXI, 3C2K, 3C2L, 3C2M, 3GDX, 3ISB, 3ISC, 3ISD, 3JPN, 3JPO, 3JPP, 3JPQ, 3JPR, 3JPS, 3JPT, 3LK9, 3MBY, 3OGU, 3RH4, 3RH5, 3RH6, 3RJE, 3RJF, 3RJG, 3RJH, 3RJI, 3RJJ, 3RJK, 3TFR, 3TFS, 4DO9, 4DOA, 4DOB, 4DOC, 4F5N, 4F5O, 4F5P, 4F5Q, 4F5R, 4GXI, 4GXJ, 4GXK, 4JWM, 4JWN, 4KLD, 4KLE, 4KLF, 4KLG, 4KLH, 4KLI, 4KLJ, 4KLL, 4KLM, 4KLO, 4KLQ, 4KLS, 4KLT, 4KLU, 4LVS, 4M2Y, 4M47, 4M9G, 4M9H, 4M9J, 4M9L, 4M9N, 4MF2, 4MF8, 4MFA, 4MFC, 4MFF, 4NLK, 4NLN, 4NLZ, 4NM1, 4NM2, 4NXZ, 4NY8, 4O5C, 4O5E, 4O5K, 4O9M, 4P2H, 4PGQ, 4PGX, 4PGY, 4PH5, 4PHA, 4PHD, 4PHE, 4PHP, 4PPX, 4R63, 4R64, 4R65, 4R66, 4RPX, 4RPY, 4RPZ, 4RQ0, 4RQ1, 4RQ2, 4RQ3, 4RQ4, 4RQ5, 4RQ6, 4RQ7, 4RQ8, 4RT2, 4RT3, 4TUP, 4TUQ, 4TUR, 4TUS, 4UAW, 4UAY, 4UAZ, 4UB1, 4UB2, 4UB3, 4UB4, 4UB5, 4UBB, 4UBC, 7ICE, 7ICF, 7ICG, 7ICH, 7ICI, 7ICJ, 7ICK, 7ICL, 7ICM, 7ICN, 7ICO, 7ICP, 7ICQ, 7ICR, 7ICS, 7ICT, 7ICU, 7ICV, 8ICA, 8ICB, 8ICC, 8ICE, 8ICF, 8ICG, 8ICH, 8ICI, 8ICJ, 8ICK, 8ICL, 8ICM, 8ICN, 8ICO, 8ICP, 8ICQ, 8ICR, 8ICS, 8ICT, 8ICU, 8ICV, 8ICW, 8ICX, 8ICY, 8ICZ, 9ICA, 9ICB, 9ICC, 9ICE, 9ICF, 9ICG, 9ICH, 9ICI, 9ICJ, 9ICK, 9ICL, 9ICM, 9ICN, 9ICO, 9ICP, 9ICQ, 9ICR, 9ICS, 9ICT, 9ICU, 9ICV, 9ICW, 9ICX, 9ICY, 5BOL, 5BOM, 5BPC, 5DB8, 5DBB, 5DBA, 5DB7, 5DBC, 5DB9, 5DB6, 4YMN, 4YN4, 4YMO, 4YMM, 4Z6C, 4Z6F, 4Z6D, 4Z6E
Dynodwyr
Cyfenwau	POLB, DNA polymerase beta
Dynodwyr allanol	OMIM: 174760 HomoloGene: 2013 GeneCards: POLB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • nucleotidyltransferase activity • microtubule binding • metal ion binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • lyase activity • enzyme binding • DNA-directed DNA polymerase activity • DNA-(apurinic or apyrimidinic site) endonuclease activity • DNA polymerase • DNA polymerase activity Cydrannau o'r gell • cytoplasm • nucleoplasm • spindle microtubule • microtubule • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • neuron apoptotic process • somatic hypermutation of immunoglobulin genes • pyrimidine dimer repair • nucleotide-excision repair, DNA gap filling • DNA-dependent DNA replication • DNA biosynthetic process • homeostasis of number of cells • response to hyperoxia • GO:0010260 heneiddio • spleen development • salivary gland morphogenesis • cellular response to DNA damage stimulus • immunoglobulin heavy chain V-D-J recombination • DNA replication • somatic diversification of immunoglobulins • base-excision repair, gap-filling • intrinsic apoptotic signaling pathway in response to DNA damage • response to ethanol • inflammatory response • lymph node development • response to gamma radiation • GO:0100026 DNA repair • GO:0097285 apoptotic process • base-excision repair • base-excision repair, DNA ligation • protein deubiquitination • double-strand break repair via nonhomologous end joining Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5423	n/a
Ensembl	ENSG00000070501	n/a
UniProt	P06746	n/a
RefSeq (mRNA)	NM_002690	n/a
RefSeq (protein)	NP_002681	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLB yw POLB a elwir hefyd yn DNA polymerase beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p11.21.

Llyfryddiaeth

• "Unencumbered Pol β lyase activity in nucleosome core particles. ". Nucleic Acids Res. 2017. PMID 28911106.
• "A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells. ". J Biol Chem. 2017. PMID 28684413.
• "POLB: A new role of DNA polymerase beta in mitochondrial base excision repair. ". DNA Repair (Amst). 2017. PMID 29129598.
• "Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. ". Nucleic Acids Res. 2017. PMID 28973450.
• "Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.". Biochemistry. 2017. PMID 28945359.