PNP

PNP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M73, 1PF7, 1PWY, 1RCT, 1RFG, 1RR6, 1RSZ, 1RT9, 1ULA, 1ULB, 1V2H, 1V3Q, 1V41, 1V45, 1YRY, 2A0W, 2A0X, 2A0Y, 2OC4, 2OC9, 2ON6, 2Q7O, 3BGS, 3D1V, 3GB9, 3GGS, 3INY, 3K8O, 3K8Q, 3PHB, 4EAR, 4EB8, 4ECE, 4GKA
Dynodwyr
Cyfenwau	PNP, NP, PRO1837, PUNP, purine nucleoside phosphorylase
Dynodwyr allanol	OMIM: 164050 HomoloGene: 227 GeneCards: PNP
EC number	2.4.2.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • phosphate ion binding • nucleoside binding • glycosyltransferase activity • purine-nucleoside phosphorylase activity • purine nucleobase binding • catalytic activity • pentosyltransferase activity Cydrannau o'r gell • cytoplasm • cytosol • intracellular anatomical structure • extracellular exosome • Cytosgerbwd • cnewyllyn cell • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen Prosesau biolegol • purine nucleotide catabolic process • purine nucleoside metabolic process • nucleoside metabolic process • inosine catabolic process • positive regulation of T cell proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • nicotinamide riboside catabolic process • NAD biosynthesis via nicotinamide riboside salvage pathway • nucleobase-containing compound metabolic process • positive regulation of alpha-beta T cell differentiation • urate biosynthetic process • neutrophil degranulation • purine-containing compound salvage • nucleotide biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4860	n/a
Ensembl	ENSG00000198805	n/a
UniProt	P00491	n/a
RefSeq (mRNA)	NM_000270	n/a
RefSeq (protein)	NP_000261	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PNP yw PNP a elwir hefyd yn Purine nucleoside phosphorylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PNP.

• NP
• PUNP
• PRO1837

Llyfryddiaeth

• "Lupus-Associated Functional Polymorphism in PNP Causes Cell Cycle Abnormalities and Interferon Pathway Activation in Human Immune Cells. ". Arthritis Rheumatol. 2017. PMID 28859258.
• "Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations. ". Biochemistry. 2017. PMID 27976868.
• "Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase. ". Biochemistry. 2016. PMID 26985580.
• "Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase. ". Proc Natl Acad Sci U S A. 2015. PMID 26305965.
• "The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning.". Nat Commun. 2015. PMID 25625196.