PMEL

PMEL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TVB, 1TVH, 3CC5, 4IS6, 5EU6, 5EU4, 5EU3
Dynodwyr
Cyfenwau	PMEL, D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100, premelanosome protein, HMB-45, HMB45
Dynodwyr allanol	OMIM: 155550 HomoloGene: 5048 GeneCards: PMEL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding Cydrannau o'r gell • multivesicular body • bilen • extracellular region • multivesicular body membrane • integral component of membrane • endosome • Cellbilen • Reticwlwm endoplasmig • melanosome • Golgi apparatus • endoplasmic reticulum membrane • integral component of plasma membrane Prosesau biolegol • melanin biosynthetic process • melanosome organization • developmental pigmentation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6490	n/a
Ensembl	ENSG00000185664	n/a
UniProt	P40967	n/a
RefSeq (mRNA)	NM_001200053 NM_001200054 NM_006928 NM_001320121 NM_001320122 NM_001384361	n/a
RefSeq (protein)	NP_001186982 NP_001186983 NP_001307050 NP_001307051 NP_008859	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PMEL yw PMEL a elwir hefyd yn Melanocyte protein PMEL a Premelanosome protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PMEL.

• P1
• SI
• SIL
• ME20
• P100
• SILV
• ME20M
• gp100
• ME20-M
• PMEL17
• D12S53E

Llyfryddiaeth

• "The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation. ". J Biol Chem. 2016. PMID 26694611.
• "Lysophospholipid-containing membranes modulate the fibril formation of the repeat domain of a human functional amyloid, pmel17. ". J Mol Biol. 2014. PMID 25451784.
• "Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells. ". Immunology. 2017. PMID 28640942.
• "A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen. ". J Biol Chem. 2016. PMID 26917722.
• "A β-solenoid model of the Pmel17 repeat domain: insights to the formation of functional amyloid fibrils.". J Comput Aided Mol Des. 2016. PMID 26754844.