PLXNB1

PLXNB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JPH, 2OS6, 2R2O, 2REX, 3HM6, 3OL2, 3SU8, 3SUA
Dynodwyr
Cyfenwau	PLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
Dynodwyr allanol	OMIM: 601053 HomoloGene: 130508 GeneCards: PLXNB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GTPase activating protein binding • semaphorin receptor activity • semaphorin receptor binding • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • signaling receptor activity Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • semaphorin receptor complex • integral component of plasma membrane • extracellular region • intracellular anatomical structure Prosesau biolegol • ossification involved in bone maturation • negative regulation of cell adhesion • neuron projection morphogenesis • GO:0007243 intracellular signal transduction • positive regulation of axonogenesis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • regulation of cell shape • axon extension • negative regulation of osteoblast proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • regulation of cytoskeleton organization • semaphorin-plexin signaling pathway • GO:0072468 signal transduction • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • G protein-coupled receptor signaling pathway • regulation of cell migration • semaphorin-plexin signaling pathway involved in axon guidance • inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5364	n/a
Ensembl	ENSG00000164050	n/a
UniProt	O43157	n/a
RefSeq (mRNA)	NM_001130082 NM_002673	n/a
RefSeq (protein)	NP_001123554 NP_002664	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLXNB1 yw PLXNB1 a elwir hefyd yn Plexin B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLXNB1.

• SEP
• PLXN5
• PLEXIN-B1

Llyfryddiaeth

• "Function of mutant and wild-type plexinb1 in prostate cancer cells. ". Prostate. 2013. PMID 23775445.
• "A dual binding mode for RhoGTPases in plexin signalling. ". PLoS Biol. 2011. PMID 21912513.
• "Role of Plexin B1 in a Breast Cancer Cohort of Pakistani Patients and its Contribution Towards Cancer Metastasis as Indicated by an In VitroModel. ". Anticancer Res. 2017. PMID 28739743.
• "Plexin-B1 indirectly affects glioma invasiveness and angiogenesis by regulating the RhoA/αvβ3 signaling pathway and SRPK1. ". Tumour Biol. 2016. PMID 26944058.
• "Plexin-B1 signalling promotes androgen receptor translocation to the nucleus.". Oncogene. 2016. PMID 25982277.