PLK4

PLK4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2N19, 3COK, 4JXF, 4N7V, 4N7Z, 4N9J, 4YUR, 4YYP
Dynodwyr
Cyfenwau	PLK4, SAK, STK18, MCCRP2, polo like kinase 4
Dynodwyr allanol	OMIM: 605031 HomoloGene: 7962 GeneCards: PLK4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • identical protein binding Cydrannau o'r gell • cytoplasm • centrosome • deuterosome • XY body • nucleolus • centriole • cleavage furrow • Cytosgerbwd • cnewyllyn cell • cytosol Prosesau biolegol • trophoblast giant cell differentiation • phosphorylation • de novo centriole assembly involved in multi-ciliated epithelial cell differentiation • G2/M transition of mitotic cell cycle • centriole replication • positive regulation of centriole replication • ciliary basal body-plasma membrane docking • regulation of G2/M transition of mitotic cell cycle • protein phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10733	n/a
Ensembl	ENSG00000142731	n/a
UniProt	O00444	n/a
RefSeq (mRNA)	NM_001190799 NM_001190801 NM_014264	n/a
RefSeq (protein)	NP_001177728 NP_001177730 NP_055079	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLK4 yw PLK4 a elwir hefyd yn Serine/threonine-protein kinase PLK4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q28.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLK4.

• SAK
• STK18
• MCCRP2

Llyfryddiaeth

• "A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. ". EMBO Rep. 2016. PMID 26755742.
• "A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome. ". Andrology. 2016. PMID 26452337.
• "Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage. ". Fertil Steril. 2017. PMID 28238495.
• "Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton. ". Cancer Res. 2017. PMID 27872092.
• "Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy.". Eur J Hum Genet. 2016. PMID 27650967.