PLK1

PLK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34, 3P35, 3P36, 3P37, 3Q1I, 3RQ7, 3THB, 4A4L, 4A4O, 4DFW, 4E67, 4E9C, 4E9D, 4H5X, 4H71, 4HAB, 4HCO, 4HY2, 4J52, 4J53, 4LKL, 4LKM, 4O56, 4O6W, 4O9W, 4RCP, 4WHH, 4WHL, 4X9R, 4X9V, 4X9W, 2OGQ, 5J19
Dynodwyr
Cyfenwau	PLK1, PLK, STPK13, polo like kinase 1
Dynodwyr allanol	OMIM: 602098 HomoloGene: 3690 GeneCards: PLK1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • microtubule binding; • kinase activity; • GO:0001948, GO:0016582 protein binding; • anaphase-promoting complex binding; • protein kinase binding; • protein serine/threonine kinase activity; • magnesium ion binding; • protein kinase activity; • ATP binding; • identical protein binding;
Cydrannau o'r gell	• cytosol; • centrosome; • spindle pole; • microtubule cytoskeleton; • spindle; • nucleoplasm; • Cromosom; • microtubule organizing center; • midbody; • spindle microtubule; • spindle midzone; • chromatin; • synaptonemal complex; • chromosome, centromeric region; • Cytosgerbwd; • cnewyllyn cell; • kinetochore; • cytoplasm; • centriole; • centriolar satellite;
Prosesau biolegol	• phosphorylation; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • establishment of protein localization; • synaptonemal complex disassembly; • mitotic cytokinesis; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • homologous chromosome segregation; • regulation of mitotic spindle assembly; • mitotic spindle assembly checkpoint signaling; • regulation of cell cycle; • Cellraniad; • mitotic nuclear membrane disassembly; • G2/M transition of mitotic cell cycle; • positive regulation of peptidyl-threonine phosphorylation; • GO:0035404 peptidyl-serine phosphorylation; • microtubule bundle formation; • protein ubiquitination; • protein destabilization; • regulation of mitotic cell cycle; • positive regulation of ubiquitin-protein transferase activity; • positive regulation of proteolysis; • mitotic sister chromatid segregation; • regulation of mitotic metaphase/anaphase transition; • cell cycle; • anaphase-promoting complex-dependent catabolic process; • cell population proliferation; • regulation of protein binding; • protein localization to chromatin; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • female meiosis chromosome segregation; • positive regulation of protein localization to nucleus; • sister chromatid cohesion; • regulation of cell cycle G2/M phase transition; • GO:0007067 Mitosis; • protein phosphorylation; • centrosome cycle; • nuclear membrane disassembly; • protein localization to nuclear envelope; • ciliary basal body-plasma membrane docking; • GO:0090623, GO:1903835, GO:0007092, GO:0051488, GO:0051487 positive regulation of ubiquitin protein ligase activity; • regulation of G2/M transition of mitotic cell cycle; • regulation of cytokinesis; • mitotic G2 DNA damage checkpoint signaling; • protein localization to organelle; • regulation of mitotic cell cycle phase transition; • ubiquitin-dependent protein catabolic process; • establishment of mitotic spindle orientation; • regulation of protein localization to cell cortex;
	Sources:Amigo / QuickGO
Orthologau
	5347
	n/a
	ENSG00000166851
	n/a
	P53350
	n/a
	NM_005030
	n/a
	NP_005021
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLK1 yw PLK1 a elwir hefyd yn Polo like kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p12.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLK1.

PLK
STPK13

Llyfryddiaeth[golygu | golygu cod]

"Dasatinib synergises with irinotecan to suppress hepatocellular carcinoma via inhibiting the protein synthesis of PLK1. ". Br J Cancer. 2017. PMID 28267710.
"Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma. ". Cancer Lett. 2017. PMID 28235541.
"Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication. ". Hepatology. 2017. PMID 28445592.
"Comparative Analysis of a FRET-based PLK1 Kinase Assay to Identify PLK1 inhibitors for Chemotherapy. ". Anticancer Res. 2017. PMID 28314279.
"PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis.". Childs Nerv Syst. 2017. PMID 28283778.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] PLK1 - Cronfa NCBI

[1]

[2]